Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma

Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma

Abstract The chloride channel transmembrane protein 16A (TMEM16A) possesses a calcium-activated property linked to tumor-promoting malignant phenotype and electrophysiological stability. Numerous studies have shown that TMEM16A exhibits aberrant amplification in various squamous cell carcinomas such...

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Bibliographic Details
Main Authors: Yutian Zheng, Lin Meng, Like Qu, Chuanke Zhao, Lixin Wang, Jiayi Ma, Caiyun Liu, Chengchao Shou
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
Esophageal squamous cell carcinoma (ESCC)
TMEM16A
Monoclonal antibodies (mAb)
Cetuximab
Anti-metastasis
Online Access:https://doi.org/10.1186/s12967-024-05830-3
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