Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation
To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18–40 years) were enrolled in an...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/394934 |
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| author | Davide Francomano Lorenzo M. Donini Andrea Lenzi Antonio Aversa |
| author_facet | Davide Francomano Lorenzo M. Donini Andrea Lenzi Antonio Aversa |
| author_sort | Davide Francomano |
| collection | DOAJ |
| description | To elucidate whether adrenergic overtone is involved in the pathophysiology of men with
lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia
index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18–40 years) were enrolled in an 8-week, double-blind, placebo-controlled, crossover study and compared with 10 age-matched controls without LL-PE. Primary endpoints were PAT modifications induced by vardenafil 10 mg on demand. Secondary endpoints were the
improvement in intravaginal ejaculatory latency time (IELT) as measured by the stopwatch technique and variations in anxiety scores at Stai-X1 for state-anxiety and Stai-X2 for trait-anxiety. At baseline, men with LL-PE showed higher RHI variation (), Stai-X1 and Stai X2 scores (, resp.), and prolactin levels () compared with controls. Vardenafil treatment markedly reduced RHI variation in men with LL-PE ()
when compared with placebo. Mean changes in geometric IELT were higher after taking
vardenafil (0.6 ± 0.3 versus 4.5 ± 1.1 min, ) when compared with placebo. STAI-X1 and STAI-X2 scores fell within the normal range after treatment with vardenafil (). Vardenafil was an effective treatment in men with LL-PE; improvements of IELT may be due to increased NO production which is able to reduce adrenergic overactivity and anxiety levels. |
| format | Article |
| id | doaj-art-6fde1e2628464a4bbb59ebef934268e6 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6fde1e2628464a4bbb59ebef934268e62025-02-03T05:54:29ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/394934394934Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature EjaculationDavide Francomano0Lorenzo M. Donini1Andrea Lenzi2Antonio Aversa3Department of Experimental Medicine, Section of Medical Pathophysiology, viale Regina Elena 324, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, Section of Medical Pathophysiology, viale Regina Elena 324, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, Section of Medical Pathophysiology, viale Regina Elena 324, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, Section of Medical Pathophysiology, viale Regina Elena 324, Sapienza University of Rome, 00161 Rome, ItalyTo elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18–40 years) were enrolled in an 8-week, double-blind, placebo-controlled, crossover study and compared with 10 age-matched controls without LL-PE. Primary endpoints were PAT modifications induced by vardenafil 10 mg on demand. Secondary endpoints were the improvement in intravaginal ejaculatory latency time (IELT) as measured by the stopwatch technique and variations in anxiety scores at Stai-X1 for state-anxiety and Stai-X2 for trait-anxiety. At baseline, men with LL-PE showed higher RHI variation (), Stai-X1 and Stai X2 scores (, resp.), and prolactin levels () compared with controls. Vardenafil treatment markedly reduced RHI variation in men with LL-PE () when compared with placebo. Mean changes in geometric IELT were higher after taking vardenafil (0.6 ± 0.3 versus 4.5 ± 1.1 min, ) when compared with placebo. STAI-X1 and STAI-X2 scores fell within the normal range after treatment with vardenafil (). Vardenafil was an effective treatment in men with LL-PE; improvements of IELT may be due to increased NO production which is able to reduce adrenergic overactivity and anxiety levels.http://dx.doi.org/10.1155/2013/394934 |
| spellingShingle | Davide Francomano Lorenzo M. Donini Andrea Lenzi Antonio Aversa Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation International Journal of Endocrinology |
| title | Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation |
| title_full | Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation |
| title_fullStr | Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation |
| title_full_unstemmed | Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation |
| title_short | Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation |
| title_sort | peripheral arterial tonometry to measure the effects of vardenafil on sympathetic tone in men with lifelong premature ejaculation |
| url | http://dx.doi.org/10.1155/2013/394934 |
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