Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome
Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription f...
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| Language: | English |
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BioMed Central
2019-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2019-17-1-e8.pdf |
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| author | Chilakamarti V. Ramana |
| author_facet | Chilakamarti V. Ramana |
| author_sort | Chilakamarti V. Ramana |
| collection | DOAJ |
| description | Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, NF-kB, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions. |
| format | Article |
| id | doaj-art-6fda938b6ed0456d9c1f446a0191becb |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-6fda938b6ed0456d9c1f446a0191becb2025-02-03T01:56:33ZengBioMed CentralGenomics & Informatics2234-07422019-03-0117110.5808/GI.2019.17.1.e8547Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptomeChilakamarti V. Ramana0 Department of Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03766, USAAlveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, NF-kB, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.http://genominfo.org/upload/pdf/gi-2019-17-1-e8.pdfgene signaturelung injurylung type II cells,microarrayssignal transduction pathwaystranscription factor profiling |
| spellingShingle | Chilakamarti V. Ramana Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome Genomics & Informatics gene signature lung injury lung type II cells,microarrays signal transduction pathways transcription factor profiling |
| title | Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome |
| title_full | Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome |
| title_fullStr | Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome |
| title_full_unstemmed | Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome |
| title_short | Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome |
| title_sort | insights into the signal transduction pathways of mouse lung type ii cells revealed by transcription factor profiling in the transcriptome |
| topic | gene signature lung injury lung type II cells,microarrays signal transduction pathways transcription factor profiling |
| url | http://genominfo.org/upload/pdf/gi-2019-17-1-e8.pdf |
| work_keys_str_mv | AT chilakamartivramana insightsintothesignaltransductionpathwaysofmouselungtypeiicellsrevealedbytranscriptionfactorprofilinginthetranscriptome |