Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)

Abstract Background Immunosenescence describes the gradual remodeling of immune responses, leading to disturbed immune homeostasis and increased susceptibility of older adults for infections, neoplasia and autoimmunity. Decline in cellular immunity is associated with intrinsic changes in the T cell...

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Main Authors: Emma Keltsch, Jennifer Greiner, Lena Wahl, Ingrid Knape, Daniel Tews, Michael Denkinger, Klaus-Michael Debatin, Gudrun Strauss
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Immunity & Ageing
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Online Access:https://doi.org/10.1186/s12979-025-00524-w
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