The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study
Objective The objective of this study was to explore the ability of dual-energy computed tomography (DECT) to detect monosodium urate (MSU) crystal deposits in the kidneys and renal artery walls, and uric acid urolithiasis, in patients with gout and chronic kidney disease (CKD).Methods Patients with...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2458783 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582031893069824 |
|---|---|
| author | Tristan Pascart Elie Dauphin Chio Yokose Charlotte Jauffret Aurore Pacaud Victor Laurent Vincent Ducoulombier Hyon K. Choi Jean-François Budzik |
| author_facet | Tristan Pascart Elie Dauphin Chio Yokose Charlotte Jauffret Aurore Pacaud Victor Laurent Vincent Ducoulombier Hyon K. Choi Jean-François Budzik |
| author_sort | Tristan Pascart |
| collection | DOAJ |
| description | Objective The objective of this study was to explore the ability of dual-energy computed tomography (DECT) to detect monosodium urate (MSU) crystal deposits in the kidneys and renal artery walls, and uric acid urolithiasis, in patients with gout and chronic kidney disease (CKD).Methods Patients with gout and with stage 2–4 CKD were prospectively included in this cross-sectional study. Patients underwent renal, knee and feet DECT scans. Renal DECT scans were read for MSU-coded lesions in the kidneys, renal artery walls, and urinary tract using different post-processing settings. Characteristics of patients with and without DECT-positive lesions were compared, and the DECT parameters of these lesions were measured.Results A total of 27/31 patients with had renal DECT scans and were included in the analysis (23/27 men, mean (standard deviation) 73 (9) years old, mean eGFR 45.3 mL/min/1.73 m2 (21.0), volumes of MSU in the knees and feet ranging from 0.11 to 475.0 cm3). None of the patients exhibited deposition of MSU crystals in the kidneys. One case of calyceal calculi and one case of ureterolithiasis were observed, wrongly coded as MSU in default post-processing settings for gout but identified as uric acid in the “kidney stone” settings. Five patients had MSU-coded plaques in the renal arteries, which had DECT parameters consistent with early calcified plaques rather than MSU, and had no association with volumes of peripheral MSU deposition.Conclusion DECT is unable to detect genuine monosodium urate crystal deposits in kidneys and renal artery walls, and but can characterize chronic asymptomatic urolithiasis. |
| format | Article |
| id | doaj-art-6f9b248a9fcc4567bb0c68f6debaa719 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-6f9b248a9fcc4567bb0c68f6debaa7192025-01-30T06:18:28ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2458783The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT studyTristan Pascart0Elie Dauphin1Chio Yokose2Charlotte Jauffret3Aurore Pacaud4Victor Laurent5Vincent Ducoulombier6Hyon K. Choi7Jean-François Budzik8Department of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, FranceDepartment of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, FranceMassachusetts General Hospital, Harvard Medical School, Boston, MA, USADepartment of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, FranceDepartment of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, FranceDepartment of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, FranceDepartment of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, FranceMassachusetts General Hospital, Harvard Medical School, Boston, MA, USADepartment of Medical Imaging, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, FranceObjective The objective of this study was to explore the ability of dual-energy computed tomography (DECT) to detect monosodium urate (MSU) crystal deposits in the kidneys and renal artery walls, and uric acid urolithiasis, in patients with gout and chronic kidney disease (CKD).Methods Patients with gout and with stage 2–4 CKD were prospectively included in this cross-sectional study. Patients underwent renal, knee and feet DECT scans. Renal DECT scans were read for MSU-coded lesions in the kidneys, renal artery walls, and urinary tract using different post-processing settings. Characteristics of patients with and without DECT-positive lesions were compared, and the DECT parameters of these lesions were measured.Results A total of 27/31 patients with had renal DECT scans and were included in the analysis (23/27 men, mean (standard deviation) 73 (9) years old, mean eGFR 45.3 mL/min/1.73 m2 (21.0), volumes of MSU in the knees and feet ranging from 0.11 to 475.0 cm3). None of the patients exhibited deposition of MSU crystals in the kidneys. One case of calyceal calculi and one case of ureterolithiasis were observed, wrongly coded as MSU in default post-processing settings for gout but identified as uric acid in the “kidney stone” settings. Five patients had MSU-coded plaques in the renal arteries, which had DECT parameters consistent with early calcified plaques rather than MSU, and had no association with volumes of peripheral MSU deposition.Conclusion DECT is unable to detect genuine monosodium urate crystal deposits in kidneys and renal artery walls, and but can characterize chronic asymptomatic urolithiasis.https://www.tandfonline.com/doi/10.1080/07853890.2025.2458783Goutchronic kidney diseasedual-energy computed tomographymonosodium urateuric acid |
| spellingShingle | Tristan Pascart Elie Dauphin Chio Yokose Charlotte Jauffret Aurore Pacaud Victor Laurent Vincent Ducoulombier Hyon K. Choi Jean-François Budzik The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study Annals of Medicine Gout chronic kidney disease dual-energy computed tomography monosodium urate uric acid |
| title | The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study |
| title_full | The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study |
| title_fullStr | The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study |
| title_full_unstemmed | The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study |
| title_short | The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study |
| title_sort | role of renal dual energy computed tomography in exploring the gouty kidney the renodect study |
| topic | Gout chronic kidney disease dual-energy computed tomography monosodium urate uric acid |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2458783 |
| work_keys_str_mv | AT tristanpascart theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT eliedauphin theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT chioyokose theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT charlottejauffret theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT aurorepacaud theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT victorlaurent theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT vincentducoulombier theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT hyonkchoi theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT jeanfrancoisbudzik theroleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT tristanpascart roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT eliedauphin roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT chioyokose roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT charlottejauffret roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT aurorepacaud roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT victorlaurent roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT vincentducoulombier roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT hyonkchoi roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy AT jeanfrancoisbudzik roleofrenaldualenergycomputedtomographyinexploringthegoutykidneytherenodectstudy |