CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma
Abstract CCN1 is a matricellular protein highly expressed in esophageal squamous cell carcinoma (ESCC) but hardly detectable in esophageal adenocarcinoma (EAC). Expression of CCN1 in EAC cells leads to TRAIL-mediated apoptosis. Unlike TRAIL, which primarily triggers cell death, APRIL and BAFF promot...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86228-z |
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| author | Lingling Xing Zhenyu Jiang Ruize Xu Tong Dang Jinbao Wu Jianyuan Chai Xianmei Meng |
| author_facet | Lingling Xing Zhenyu Jiang Ruize Xu Tong Dang Jinbao Wu Jianyuan Chai Xianmei Meng |
| author_sort | Lingling Xing |
| collection | DOAJ |
| description | Abstract CCN1 is a matricellular protein highly expressed in esophageal squamous cell carcinoma (ESCC) but hardly detectable in esophageal adenocarcinoma (EAC). Expression of CCN1 in EAC cells leads to TRAIL-mediated apoptosis. Unlike TRAIL, which primarily triggers cell death, APRIL and BAFF promote cell growth via NFκB signaling. They become active ligands by Furin cleavage. This study found that CCN1 upregulated APRIL and BAFF expression in both ESCC and EAC cells but attenuated their signaling in the latter. CCN1 kept Furin stable in ESCC allowing APRIL/BAFF to signal through their common receptor BCMA properly. In EAC cells, however, expression of CCN1 lowered Furin activity and thus limited APRIL/BAFF cleavage. As a result, ESCC cells benefited from CCN1 while EAC cell viability was attenuated by it. |
| format | Article |
| id | doaj-art-6f82a4cea40a443ca79e329f1b63d31f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6f82a4cea40a443ca79e329f1b63d31f2025-01-19T12:19:27ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-86228-zCCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinomaLingling Xing0Zhenyu Jiang1Ruize Xu2Tong Dang3Jinbao Wu4Jianyuan Chai5Xianmei Meng6Inner Mongolia Institute of Digestive DiseasesInner Mongolia Institute of Digestive DiseasesInner Mongolia Institute of Digestive DiseasesInner Mongolia Institute of Digestive DiseasesInner Mongolia Institute of Digestive DiseasesInner Mongolia Institute of Digestive DiseasesInner Mongolia Institute of Digestive DiseasesAbstract CCN1 is a matricellular protein highly expressed in esophageal squamous cell carcinoma (ESCC) but hardly detectable in esophageal adenocarcinoma (EAC). Expression of CCN1 in EAC cells leads to TRAIL-mediated apoptosis. Unlike TRAIL, which primarily triggers cell death, APRIL and BAFF promote cell growth via NFκB signaling. They become active ligands by Furin cleavage. This study found that CCN1 upregulated APRIL and BAFF expression in both ESCC and EAC cells but attenuated their signaling in the latter. CCN1 kept Furin stable in ESCC allowing APRIL/BAFF to signal through their common receptor BCMA properly. In EAC cells, however, expression of CCN1 lowered Furin activity and thus limited APRIL/BAFF cleavage. As a result, ESCC cells benefited from CCN1 while EAC cell viability was attenuated by it.https://doi.org/10.1038/s41598-025-86228-zEsophageal cancerCCN1APRILBAFFBCMAFurin |
| spellingShingle | Lingling Xing Zhenyu Jiang Ruize Xu Tong Dang Jinbao Wu Jianyuan Chai Xianmei Meng CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma Scientific Reports Esophageal cancer CCN1 APRIL BAFF BCMA Furin |
| title | CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma |
| title_full | CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma |
| title_fullStr | CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma |
| title_full_unstemmed | CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma |
| title_short | CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma |
| title_sort | ccn1 promotes april baff signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma |
| topic | Esophageal cancer CCN1 APRIL BAFF BCMA Furin |
| url | https://doi.org/10.1038/s41598-025-86228-z |
| work_keys_str_mv | AT linglingxing ccn1promotesaprilbaffsignalinginesophagealsquamouscellcarcinomabutattenuatesitinesophagealadenocarcinoma AT zhenyujiang ccn1promotesaprilbaffsignalinginesophagealsquamouscellcarcinomabutattenuatesitinesophagealadenocarcinoma AT ruizexu ccn1promotesaprilbaffsignalinginesophagealsquamouscellcarcinomabutattenuatesitinesophagealadenocarcinoma AT tongdang ccn1promotesaprilbaffsignalinginesophagealsquamouscellcarcinomabutattenuatesitinesophagealadenocarcinoma AT jinbaowu ccn1promotesaprilbaffsignalinginesophagealsquamouscellcarcinomabutattenuatesitinesophagealadenocarcinoma AT jianyuanchai ccn1promotesaprilbaffsignalinginesophagealsquamouscellcarcinomabutattenuatesitinesophagealadenocarcinoma AT xianmeimeng ccn1promotesaprilbaffsignalinginesophagealsquamouscellcarcinomabutattenuatesitinesophagealadenocarcinoma |