Tranexamic acid did not attenuate the acute rise in plasma syndecan-1 in a severely injured cohort: a laboratory analysis of the PATCH clinical trial

Tranexamic acid did not attenuate the acute rise in plasma syndecan-1 in a severely injured cohort: a laboratory analysis of the PATCH clinical trial

Abstract Background Injury to the vascular endothelium occurs in up to 34% of patients acutely following severe traumatic injury and can be quantified clinically by measuring the plasma concentration of syndecan-1 (SDC-1). Tranexamic acid (TXA) attenuates endothelial damage in animal and cell cultur...

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Main Authors: Elissa M. Milford, Dusan Marjanovic, Heidi Ho, Steven Wallis, Dominik F. Draxler, Biswadev Mitra, Russell L. Gruen, Robert Medcalf, Stephen Bernard, Colin McArthur, Marc Meagele, Brian Burns, Dashiell Gantner, Michael C. Reade
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Intensive Care Medicine Experimental
Subjects:
Trauma
Tranexamic acid
Glycocalyx
Endothelium
Syndecan-1
Online Access:https://doi.org/10.1186/s40635-025-00784-2
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