Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy

Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy

Myelodysplastic syndromes (MDS) and their progression to secondary acute myeloid leukemia (sAML) are associated with an altered protein expression including extracellular matrix (ECM) components thereby promoting an inflammatory environment. Since the role of the proteoglycan biglycan (BGN) as an in...

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Bibliographic Details
Main Authors: Christoforos K. Vaxevanis, Marcus Bauer, Karthikeyan Subbarayan, Michael Friedrich, Chiara Massa, Katharina Biehl, Haifa Kathrin Al-Ali, Claudia Wickenhauser, Barbara Seliger
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
AML
MDS
extracellular matrix
biglycan
inflammasome
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2152998
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https://www.tandfonline.com/doi/10.1080/2162402X.2022.2152998

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