UHPLC-MS/MS-based untargeted metabolite profiling of Lyme neuroborreliosis

UHPLC-MS/MS-based untargeted metabolite profiling of Lyme neuroborreliosis

Abstract The diagnosis of Lyme neuroborreliosis (LNB) requires the demonstration of intrathecal synthesis of Borrelia antibodies in a patient’s cerebrospinal fluid (CSF), which involves the invasive procedure of a lumbar puncture. This study serves as a feasibility study aimed at exploring the poten...

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Main Authors: Ilari Kuukkanen, Annukka Pietikäinen, Tiia Rissanen, Saija Hurme, Elisa Kortela, Mari J. Kanerva, Jarmo Oksi, Jukka Hytönen, Maarit Karonen
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Borrelia burgdorferi
Diagnostic biomarkers
Lyme neuroborreliosis
Metabolomics
Serum analysis
UHPLC-MS/MS
Online Access:https://doi.org/10.1038/s41598-025-92189-0
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https://doi.org/10.1038/s41598-025-92189-0

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