Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Abstract Exosomes participate in the formation of the tumor metastatic microenvironment (TME) by delivering tumor‐specific substances. However, current studies mostly focus on exosomal RNA and proteins and lack an in‐depth exploration of exosomal DNA. It is discovered that PIK3CAH1047R mutant DNA in...

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Bibliographic Details
Main Authors: Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.202501792
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