Intermittent hypoxia training improves cerebral blood flow without cognitive impairment
Abstract Objective Brief exposure to intermittent hypoxia has been shown to potentially induce protective effects in the body. Animal studies suggest that intermittent hypoxia could increase cerebral blood flow and confer resistance to subsequent hypoxic–ischemic injury, yet clinical investigations...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.52248 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592647207780352 |
|---|---|
| author | Qihan Zhang Qing Wang Feiyang Jin Dan Huang Xunming Ji Yuan Wang |
| author_facet | Qihan Zhang Qing Wang Feiyang Jin Dan Huang Xunming Ji Yuan Wang |
| author_sort | Qihan Zhang |
| collection | DOAJ |
| description | Abstract Objective Brief exposure to intermittent hypoxia has been shown to potentially induce protective effects in the body. Animal studies suggest that intermittent hypoxia could increase cerebral blood flow and confer resistance to subsequent hypoxic–ischemic injury, yet clinical investigations are limited. This study aimed to evaluate the impact of a moderate short‐term intermittent hypoxia protocol on cerebral blood flow and cognitive performance. Methods Subjects who met the inclusion criteria were recruited to this study and randomized into the intermittent hypoxia group or the control group, which receives intermittent hypoxia training and sham‐intermittent hypoxia training, respectively. Cerebral hemodynamics, cognitive performance, cerebral perfusion pressure, and oxygen saturation were assessed before and after the intervention. Results A total of 100 healthy participants were included in this study. Compared to the control group, the intermittent hypoxia group exhibited higher peak systolic blood flow velocity (108.64 ± 22.53 vs. 100.21 ± 19.06, p = 0.049) and cerebrovascular conduction index (0.74 ± 0.17 vs. 0.66 ± 0.21, p = 0.027), and lower cerebrovascular resistance index (1.41 ± 0.29 vs. 1.54 ± 0.36, p = 0.044) following intermittent hypoxia training. Additionally, within‐group comparisons revealed that intermittent hypoxia training led to increased cerebral blood flow velocity, elevated cerebrovascular conductance index, and decreased cerebrovascular resistance index (p < 0.05). Other indicators including cognitive function, cerebral perfusion pressure, and oxygen saturation did not exhibit significant differences between groups. Interpretation These findings revealed that intermittent hypoxia may represent a safe and effective strategy for improving cerebral blood flow. |
| format | Article |
| id | doaj-art-6f03a4d90eef46ad8576d801dc566b4d |
| institution | Kabale University |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-6f03a4d90eef46ad8576d801dc566b4d2025-01-21T05:41:42ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-01-01121869610.1002/acn3.52248Intermittent hypoxia training improves cerebral blood flow without cognitive impairmentQihan Zhang0Qing Wang1Feiyang Jin2Dan Huang3Xunming Ji4Yuan Wang5Department of Neurology, Xuanwu Hospital Capital Medical University Beijing ChinaDepartment of Neurology, Xuanwu Hospital Capital Medical University Beijing ChinaDepartment of Neurology, Xuanwu Hospital Capital Medical University Beijing ChinaDevelopment Coordination Office Beijing Xiaotangshan Hospital Beijing ChinaDepartment of Neurosurgery, Xuanwu Hospital Capital Medical University Beijing ChinaDepartment of Neurology, Xuanwu Hospital Capital Medical University Beijing ChinaAbstract Objective Brief exposure to intermittent hypoxia has been shown to potentially induce protective effects in the body. Animal studies suggest that intermittent hypoxia could increase cerebral blood flow and confer resistance to subsequent hypoxic–ischemic injury, yet clinical investigations are limited. This study aimed to evaluate the impact of a moderate short‐term intermittent hypoxia protocol on cerebral blood flow and cognitive performance. Methods Subjects who met the inclusion criteria were recruited to this study and randomized into the intermittent hypoxia group or the control group, which receives intermittent hypoxia training and sham‐intermittent hypoxia training, respectively. Cerebral hemodynamics, cognitive performance, cerebral perfusion pressure, and oxygen saturation were assessed before and after the intervention. Results A total of 100 healthy participants were included in this study. Compared to the control group, the intermittent hypoxia group exhibited higher peak systolic blood flow velocity (108.64 ± 22.53 vs. 100.21 ± 19.06, p = 0.049) and cerebrovascular conduction index (0.74 ± 0.17 vs. 0.66 ± 0.21, p = 0.027), and lower cerebrovascular resistance index (1.41 ± 0.29 vs. 1.54 ± 0.36, p = 0.044) following intermittent hypoxia training. Additionally, within‐group comparisons revealed that intermittent hypoxia training led to increased cerebral blood flow velocity, elevated cerebrovascular conductance index, and decreased cerebrovascular resistance index (p < 0.05). Other indicators including cognitive function, cerebral perfusion pressure, and oxygen saturation did not exhibit significant differences between groups. Interpretation These findings revealed that intermittent hypoxia may represent a safe and effective strategy for improving cerebral blood flow.https://doi.org/10.1002/acn3.52248 |
| spellingShingle | Qihan Zhang Qing Wang Feiyang Jin Dan Huang Xunming Ji Yuan Wang Intermittent hypoxia training improves cerebral blood flow without cognitive impairment Annals of Clinical and Translational Neurology |
| title | Intermittent hypoxia training improves cerebral blood flow without cognitive impairment |
| title_full | Intermittent hypoxia training improves cerebral blood flow without cognitive impairment |
| title_fullStr | Intermittent hypoxia training improves cerebral blood flow without cognitive impairment |
| title_full_unstemmed | Intermittent hypoxia training improves cerebral blood flow without cognitive impairment |
| title_short | Intermittent hypoxia training improves cerebral blood flow without cognitive impairment |
| title_sort | intermittent hypoxia training improves cerebral blood flow without cognitive impairment |
| url | https://doi.org/10.1002/acn3.52248 |
| work_keys_str_mv | AT qihanzhang intermittenthypoxiatrainingimprovescerebralbloodflowwithoutcognitiveimpairment AT qingwang intermittenthypoxiatrainingimprovescerebralbloodflowwithoutcognitiveimpairment AT feiyangjin intermittenthypoxiatrainingimprovescerebralbloodflowwithoutcognitiveimpairment AT danhuang intermittenthypoxiatrainingimprovescerebralbloodflowwithoutcognitiveimpairment AT xunmingji intermittenthypoxiatrainingimprovescerebralbloodflowwithoutcognitiveimpairment AT yuanwang intermittenthypoxiatrainingimprovescerebralbloodflowwithoutcognitiveimpairment |