Diet restriction and exercise alleviate cognitive reduction of high fat diet (HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway through activating AMPK/SIRT1 signal pathway and suppressing TLR4 signal pathway

Diet restriction and exercise alleviate cognitive reduction of high fat diet (HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway through activating AMPK/SIRT1 signal pathway and suppressing TLR4 signal pathway

Obesity, caused by excessive energy, leads to body weight gain and various diseases, including cognitive impairment. Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity. However, further exploration is needed to unde...

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Bibliographic Details
Main Authors: Hu Zhang, Ye Zhang, Jiling Liang, Jiahang Li, Miao He, Xin Liu, Jielun Huang, Minghui Wang, Jingjing Fan, Ning Chen
Format: Article
Language:English
Published: Tsinghua University Press 2024-11-01
Series:Food Science and Human Wellness
Subjects:
cognitive capacity
exercise intervention
diet restriction
inflammation
insulin signaling pathway
obesity
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2023.9250053
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https://www.sciopen.com/article/10.26599/FSHW.2023.9250053

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