Therapeutic potential of fisetin in hepatic steatosis: Insights into autophagy pathway regulation and endoplasmic reticulum stress alleviation in high-fat diet-fed mice.

Therapeutic potential of fisetin in hepatic steatosis: Insights into autophagy pathway regulation and endoplasmic reticulum stress alleviation in high-fat diet-fed mice.

Non-alcoholic fatty liver disease (NAFLD) is a common condition with limited FDA-approved treatments due to its complex pathogenesis. Metabolic stress-induced lipotoxicity triggers the unfolded protein response, leading to the development of NAFLD through inflammation and apoptosis. Moreover, metabo...

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Main Authors: Mahboobe Sattari, Mohammad Esmaeil Shahaboddin, Maryam Akhavan Taheri, Ehsan Khalili, Ozra Tabatabaei-Malazy, Golnaz Goodarzi, Sadra Samavarchi Tehrani, Reza Meshkani, Ghodratollah Panahi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0322335
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