Dual action of pyrimidine derivatives: Targeting tamoxifen resistance in breast cancer

Dual action of pyrimidine derivatives: Targeting tamoxifen resistance in breast cancer

Introduction: Approximately 70 % of patients with breast cancer (BC) have estrogen receptor (ER)-positive tumors. Endocrine therapy is the principal treatment for these patients. Tamoxifen (TAM), a selective ER modulator, is commonly administered to premenopausal patients with ER-positive BC. Howeve...

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Main Authors: Jie Yuan, Geng Wang, Narasimha M. Beeraka, Hua Zhang, Qun Wang, Danfeng Zhang, Minghua Wang, Akshay Ravish, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Vladimir N. Nikolenko, Basappa Basappa, Li Yang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Translational Oncology
Subjects:
Breast cancer
TAM resistance
EMT
Wnt/β-catenin
NF-κB
Xenograft model
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001494
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