Single-cell transcriptome integrated with genome-wide association study reveals heterogeneity of carotid and femoral plaques and its association with plaque stability

Single-cell transcriptome integrated with genome-wide association study reveals heterogeneity of carotid and femoral plaques and its association with plaque stability

Abstract Carotid and femoral plaques exhibit varying degrees of stability; however, the relationships of different genes/cell types with plaque embolism are poorly understood. We evaluated differential gene/cell expression and investigated the cells/genes associated with carotid and femoral artery p...

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Main Authors: Xinhuang Hou, Zhipeng Li, Jun Lin, Wei Lin, Luyao Li, Xiaoqi Zheng, Xiaoling Lai, Lin Zhu, Pingfan Guo, Fanggang Cai, Jinchi Zhang, Wanglong Li, Changwei Yang, Yiquan Dai
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Single-cell sequencing
Carotid and femoral
Atherosclerosis
Plaque embolism
Online Access:https://doi.org/10.1038/s41598-025-96434-4
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