First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In Vitro
A 60-year-old man presented with pneumococcal meningitis which did not respond to the ceftriaxone therapy, in spite of in-vitro susceptibility (minimal inhibitory concentration of 0.016 μg/dLit) of the isolated organism to this antibacterial agent, although ceftriaxone is still the drug of choice fo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2011/485952 |
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| author | Maryam Mojtabavi Hamid Reza Naderi Ashraf Tavanaee Sani Mahmood Bagheri Kiarash Ghazvini |
| author_facet | Maryam Mojtabavi Hamid Reza Naderi Ashraf Tavanaee Sani Mahmood Bagheri Kiarash Ghazvini |
| author_sort | Maryam Mojtabavi |
| collection | DOAJ |
| description | A 60-year-old man presented with pneumococcal meningitis which did not respond to the ceftriaxone therapy, in spite of in-vitro susceptibility (minimal inhibitory concentration of 0.016 μg/dLit) of the isolated organism to this antibacterial agent, although ceftriaxone is still the drug of choice for such pneumococcal meningitis. Review of published articles revealed no report of clinical resistance in organisms which were susceptible to the same antimicrobial agent in vitro. This alarming emergence of isolates with in vivo resistance should be considered and even could lead to a shift in the empirical antibiotic therapy for pneumococcal infections. |
| format | Article |
| id | doaj-art-6e7c385b849b459f942b0944b60c7228 |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-6e7c385b849b459f942b0944b60c72282025-02-03T05:51:04ZengWileyCase Reports in Pulmonology2090-68462090-68542011-01-01201110.1155/2011/485952485952First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In VitroMaryam Mojtabavi0Hamid Reza Naderi1Ashraf Tavanaee Sani2Mahmood Bagheri3Kiarash Ghazvini4Department of infectious disease, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of infectious disease, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of infectious disease, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of infectious disease, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMicrobiology and Virology Research Center, Ghaem University Hospital and Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9188974645, IranA 60-year-old man presented with pneumococcal meningitis which did not respond to the ceftriaxone therapy, in spite of in-vitro susceptibility (minimal inhibitory concentration of 0.016 μg/dLit) of the isolated organism to this antibacterial agent, although ceftriaxone is still the drug of choice for such pneumococcal meningitis. Review of published articles revealed no report of clinical resistance in organisms which were susceptible to the same antimicrobial agent in vitro. This alarming emergence of isolates with in vivo resistance should be considered and even could lead to a shift in the empirical antibiotic therapy for pneumococcal infections.http://dx.doi.org/10.1155/2011/485952 |
| spellingShingle | Maryam Mojtabavi Hamid Reza Naderi Ashraf Tavanaee Sani Mahmood Bagheri Kiarash Ghazvini First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In Vitro Case Reports in Pulmonology |
| title | First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In Vitro |
| title_full | First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In Vitro |
| title_fullStr | First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In Vitro |
| title_full_unstemmed | First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In Vitro |
| title_short | First Report of a Case of Pneumococcal Meningitis Which Did Not Respond to the Ceftriaxone Therapy despite the Isolated Organism Being Sensitive to This Antibiotic In Vitro |
| title_sort | first report of a case of pneumococcal meningitis which did not respond to the ceftriaxone therapy despite the isolated organism being sensitive to this antibiotic in vitro |
| url | http://dx.doi.org/10.1155/2011/485952 |
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