Mannheimia haemolytica isogenic capsular and LPS-sialylation gene deletion mutants are attenuated in a calf lung challenge model

Mannheimia haemolytica isogenic capsular and LPS-sialylation gene deletion mutants are attenuated in a calf lung challenge model

ABSTRACT Bovine respiratory disease complex (BRDC) is a multifactorial syndrome that involves complex interactions between environment, bacterial/viral pathogens, and the host. Mannheimia haemolytica is the most significant bacterial pathogen associated with BRDC. This study investigated the virulen...

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Main Authors: Harish Menghwar, Fred M. Tatum, Robert E. Briggs, Anna K. Goldkamp, Bradley O. Chriswell, Carly Kanipe, Hao Ma, Eduardo Casas, Rohana P. Dassanayake
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:Microbiology Spectrum
Subjects:
bovine lung challenge
capsule
LPS sialylation
M. haemolytica
mutant
virulence factors
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00283-25
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https://journals.asm.org/doi/10.1128/spectrum.00283-25

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