Preliminary study of utilizing a patient derived tumor spheroid model to augment precision therapy in metastatic brain tumors

Preliminary study of utilizing a patient derived tumor spheroid model to augment precision therapy in metastatic brain tumors

Abstract Treating metastatic brain tumors remains a significant challenge. This study introduces and applies the Patient-Derived Tumor Spheroid (PDTS) system, an ex vivo model for precision drug testing on metastatic brain tumor. The PDTS system utilizes a decellularized extracellular matrix (dECM)...

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Main Authors: Chun-Jen Chang, Kai-Wen Kan, Yu-Yin Shih, Yu-Han Nan, Yu-Chung Juan, Chih-Hsiu Tu, Chen-Ting Yang, Wei-Lin Hsu, Der-Yang Cho, Ming-You Shie, Yi-Wen Chen, Chun-Chung Chen
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Metastatic brain tumor
Patient-derived organoid
Patient-derived tumor spheroids
Micro-organosphere
Precision oncology
Online Access:https://doi.org/10.1038/s41598-024-83409-0
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https://doi.org/10.1038/s41598-024-83409-0

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