A virus based vaccine combined with IL12 gene therapy eradicates aggressive melanoma

A virus based vaccine combined with IL12 gene therapy eradicates aggressive melanoma

Abstract Our study introduces a novel bacteriophage-based vaccine strategy and evaluates its antitumor efficacy, both as a standalone therapy and in combination with gene electrotransfer (GET) of interleukin-12 (IL-12) plasmids. Using phage display technology, we produced engineered M13 bacteriophag...

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Bibliographic Details
Main Authors: Nuša Brišar, Katja Šuster, Simona Kranjc Brezar, Andrej Cör
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Immunotherapy
Bacteriophages
Bacteriophage display technology
Bacteriophage vaccine
Interleukin
Gene electrotransfer
Online Access:https://doi.org/10.1038/s41598-025-04026-z
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https://doi.org/10.1038/s41598-025-04026-z

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