Pathological Characteristics of Pregnant Tree Shrews Infected by Zoonotic Hepatitis E Virus Genotype and the Effect of Estrogen on Virus Replication

Pathological Characteristics of Pregnant Tree Shrews Infected by Zoonotic Hepatitis E Virus Genotype and the Effect of Estrogen on Virus Replication

Hepatitis E, caused by the hepatitis E virus (HEV), is a zoonotic disease that extends beyond hepatocellular necrosis to replicate in multiple organs. While most infections are self-limiting, HEV infection during pregnancy is associated with severe outcomes, including acute liver failure, preterm de...

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Main Authors: Peiying Zhu, Guojun Wang, Veerasak Punyapornwithaya, Chalita Jainonthee, Jijing Tian, Yan Liu, Fanan Suksawat, Sunpetch Angkititrakul, Yuchen Nan, Zailei Li, Xinhui Duan, Wengui Li
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Veterinary Sciences
Subjects:
hepatitis E virus
extrahepatic replication
estrogen
pregnant infection mode
adverse pregnancy
tree shrew
Online Access:https://www.mdpi.com/2306-7381/12/5/483
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