New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke

New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke

Ischemic stroke is a high-mortality disease that urgently requires new therapeutic strategies. Insufficient cerebral blood supply can induce poly (ADP-ribose) polymerase (PARP) activation and mitochondrial dysfunction, leading to tissue damage and motor dysfunction. We demonstrate that the expressio...

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Bibliographic Details
Main Authors: Yang Cai, Hongfeng Gu, Lu Li, Xue Liu, Ying Bai, Ling Shen, Bing Han, Yungen Xu, Honghong Yao
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
PARP7
Mitochondrial dysfunction
Neuroprotective agents
Pharmacology
Stroke
Drug design
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004535
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