Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression
Abstract Background It has been reported that the cognitive responses to physical activity (PA) in postmenopausal women vary by parity status, and women with higher parity show a significant association between PA and cognitive function. However, the potential pathways mediating the relationship bet...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-025-03548-y |
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| author | Xiaotong Chen Kai Wei Shanshan Peng Na Liu Leqi He Biying Wu Meifang Shi Yong Lin |
| author_facet | Xiaotong Chen Kai Wei Shanshan Peng Na Liu Leqi He Biying Wu Meifang Shi Yong Lin |
| author_sort | Xiaotong Chen |
| collection | DOAJ |
| description | Abstract Background It has been reported that the cognitive responses to physical activity (PA) in postmenopausal women vary by parity status, and women with higher parity show a significant association between PA and cognitive function. However, the potential pathways mediating the relationship between PA and cognitive function in women with higher parity remain unclear. The objective of this study was to examine this association in Chinese cohort and further investigate the mediating pathways. Methods A total of 2296 postmenopausal women were enrolled from the Baoshan District, from April to December 2020. All participant information was collected through interviewer-administered questionnaires or measurements, including personal information, medical history, lifestyle, body mass index (BMI), cognitive function, nutritional status, and depression status. In this cross-sectional study, generalized linear regression models and the chain-mediation analysis were used to examine the relationship between PA and cognitive function and the mediating pathways. Results There was a significant relationship between PA and cognitive function in the high-parity group (≥ three births). In the fully adjusted generalized linear regression model, PA was significantly associated with cognitive function [β: 0.795, 95% confidence interval (CI): 0.251–1.340, P < 0.05]. The chain-mediation analysis showed that depression and nutritional status were two significant mediators, contributing 37.96% of the indirect effect of the overall effect. Conclusions Our findings suggest that PA is beneficial for women (≥ three births) to maintain cognitive function, and these benefits are mediated by depression and nutritional status. |
| format | Article |
| id | doaj-art-6e38e3ffa8404ec09229a4969f47264d |
| institution | Kabale University |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj-art-6e38e3ffa8404ec09229a4969f47264d2025-01-19T12:37:34ZengBMCBMC Women's Health1472-68742025-01-012511910.1186/s12905-025-03548-yAssociation between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depressionXiaotong Chen0Kai Wei1Shanshan Peng2Na Liu3Leqi He4Biying Wu5Meifang Shi6Yong Lin7Department of Laboratory Medicine, Jing’an District Central Hospital of Shanghai, Jing’an Branch Affiliated to Huashan Hospital, Fudan UniversityDepartment of Pharmacy, Guizhou Provincial People’s HospitalHealth Management Center, Huashan Hospital, Fudan UniversityDepartment of Laboratory Medicine, Huashan Hospital, Fudan UniversityDepartment of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai, Fudan UniversityDepartment of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai, Fudan UniversityYouyi Road Community Health Service Centre for Baoshan DistrictDepartment of Laboratory Medicine, Huashan Hospital, Fudan UniversityAbstract Background It has been reported that the cognitive responses to physical activity (PA) in postmenopausal women vary by parity status, and women with higher parity show a significant association between PA and cognitive function. However, the potential pathways mediating the relationship between PA and cognitive function in women with higher parity remain unclear. The objective of this study was to examine this association in Chinese cohort and further investigate the mediating pathways. Methods A total of 2296 postmenopausal women were enrolled from the Baoshan District, from April to December 2020. All participant information was collected through interviewer-administered questionnaires or measurements, including personal information, medical history, lifestyle, body mass index (BMI), cognitive function, nutritional status, and depression status. In this cross-sectional study, generalized linear regression models and the chain-mediation analysis were used to examine the relationship between PA and cognitive function and the mediating pathways. Results There was a significant relationship between PA and cognitive function in the high-parity group (≥ three births). In the fully adjusted generalized linear regression model, PA was significantly associated with cognitive function [β: 0.795, 95% confidence interval (CI): 0.251–1.340, P < 0.05]. The chain-mediation analysis showed that depression and nutritional status were two significant mediators, contributing 37.96% of the indirect effect of the overall effect. Conclusions Our findings suggest that PA is beneficial for women (≥ three births) to maintain cognitive function, and these benefits are mediated by depression and nutritional status.https://doi.org/10.1186/s12905-025-03548-yPhysical activityCognitive functionParityDepressionNutritional status |
| spellingShingle | Xiaotong Chen Kai Wei Shanshan Peng Na Liu Leqi He Biying Wu Meifang Shi Yong Lin Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression BMC Women's Health Physical activity Cognitive function Parity Depression Nutritional status |
| title | Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression |
| title_full | Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression |
| title_fullStr | Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression |
| title_full_unstemmed | Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression |
| title_short | Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression |
| title_sort | association between physical activity and cognitive function in post menopausal women with high parity the chain mediating effects of nutritional status and depression |
| topic | Physical activity Cognitive function Parity Depression Nutritional status |
| url | https://doi.org/10.1186/s12905-025-03548-y |
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