Molecular mechanisms at the basis of the protective effect exerted by EPPS on neurodegeneration induced by prefibrillar amyloid oligomers

Molecular mechanisms at the basis of the protective effect exerted by EPPS on neurodegeneration induced by prefibrillar amyloid oligomers

Abstract It has been shown recently, without an explanation of the possible molecular mechanisms involved, that 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic (EPPS) acid effectively protects from the neurotoxicity induced by oligomers and plaques formed by the protein amyloid-β protein. Here we re...

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Main Authors: Beatrice Zarrilli, Roberto Bonanni, Marcello Belfiore, Mariagrazia Severino, Ida Cariati, Raoul Fioravanti, Giacomo Cappella, Simona Sennato, Claudio Frank, Cristiano Giordani, Virginia Tancredi, Cecilia Bombelli, Marco Diociaiuti, Giovanna D’Arcangelo
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
neurodegeneration
Alzheimer’s disease (AD)
salmon calcitonin (sCT)
4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS)
Prefibrillar Oligomers (PFOs)
Online Access:https://doi.org/10.1038/s41598-024-77859-9
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https://doi.org/10.1038/s41598-024-77859-9

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