Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheum...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/2454168 |
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| author | E. Russo M. Caprnda P. Kruzliak P. G. Conaldi C. V. Borlongan G. La Rocca |
| author_facet | E. Russo M. Caprnda P. Kruzliak P. G. Conaldi C. V. Borlongan G. La Rocca |
| author_sort | E. Russo |
| collection | DOAJ |
| description | Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies. |
| format | Article |
| id | doaj-art-6de5acd1bf5c40e7ab85c2824baeb3dd |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6de5acd1bf5c40e7ab85c2824baeb3dd2025-02-03T01:25:21ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/2454168Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration ApplicationsE. Russo0M. Caprnda1P. Kruzliak2P. G. Conaldi3C. V. Borlongan4G. La Rocca5Section of Histology and Embryology1st Department of Internal Medicine2nd Department of SurgeryDepartment of ResearchDepartment of Neurosurgery and Brain RepairSection of Histology and EmbryologyChondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.http://dx.doi.org/10.1155/2022/2454168 |
| spellingShingle | E. Russo M. Caprnda P. Kruzliak P. G. Conaldi C. V. Borlongan G. La Rocca Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications Stem Cells International |
| title | Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications |
| title_full | Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications |
| title_fullStr | Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications |
| title_full_unstemmed | Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications |
| title_short | Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications |
| title_sort | umbilical cord mesenchymal stromal cells for cartilage regeneration applications |
| url | http://dx.doi.org/10.1155/2022/2454168 |
| work_keys_str_mv | AT erusso umbilicalcordmesenchymalstromalcellsforcartilageregenerationapplications AT mcaprnda umbilicalcordmesenchymalstromalcellsforcartilageregenerationapplications AT pkruzliak umbilicalcordmesenchymalstromalcellsforcartilageregenerationapplications AT pgconaldi umbilicalcordmesenchymalstromalcellsforcartilageregenerationapplications AT cvborlongan umbilicalcordmesenchymalstromalcellsforcartilageregenerationapplications AT glarocca umbilicalcordmesenchymalstromalcellsforcartilageregenerationapplications |