Consensus representation of multiple cell–cell graphs from gene signaling pathways for cell type annotation

Consensus representation of multiple cell–cell graphs from gene signaling pathways for cell type annotation

Abstract Background Recent advancements in single-cell RNA sequencing have greatly expanded our knowledge of the heterogeneous nature of tissues. However, robust and accurate cell type annotation continues to be a major challenge, hindered by issues such as marker specificity, batch effects, and a l...

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Bibliographic Details
Main Authors: Yu-An Huang, Yue-Chao Li, Zhu-Hong You, Lun Hu, Peng-Wei Hu, Lei Wang, Yuzhong Peng, Zhi-An Huang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
Single-cell RNA sequencing
Cell type annotation
Consensus graph
Cellular communication
Pathway integration
Online Access:https://doi.org/10.1186/s12915-025-02128-8
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