Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages

Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages

Abstract The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level. However, how chromatin signatures are linked to this dynamic expression pattern across different blood cell l...

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Bibliographic Details
Main Authors: Kevin Qiu, Duc C. Vu, Leran Wang, Nicholas N. Nguyen, Anna K. Bookstaver, Katia Sol-Church, Hui Li, Thang N. Dinh, Adam N. Goldfarb, Daniel G. Tenen, Bon Q. Trinh
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Epigenetics & Chromatin
Subjects:
Chromatin structure
Configuration
Architecture
Signature
Enhancer
Promoter
Online Access:https://doi.org/10.1186/s13072-024-00556-4
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https://doi.org/10.1186/s13072-024-00556-4

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