The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats
Background: We investigated chitosan’s protective effects against tertiary butylhydroquinone (TBHQ)-induced toxicity in adult male rats, focusing on cognitive functions and oxidative stress in the brain, liver, and kidneys. Method...
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IMR Press
2025-01-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26871 |
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| author | Shahad Alahmadi Mohammed Mufadhe Alanazi Fawaz Alasmari Wedad Saeed Al-Qahtani Gadah Albasher |
| author_facet | Shahad Alahmadi Mohammed Mufadhe Alanazi Fawaz Alasmari Wedad Saeed Al-Qahtani Gadah Albasher |
| author_sort | Shahad Alahmadi |
| collection | DOAJ |
| description | Background: We investigated chitosan’s protective effects against tertiary butylhydroquinone (TBHQ)-induced toxicity in adult male rats, focusing on cognitive functions and oxidative stress in the brain, liver, and kidneys. Methods: Rats were divided into four groups (n = 8/group): (1) Control, (2) Chitosan only, (3) TBHQ only, and (4) Chitosan + TBHQ. Results: TBHQ exposure led to significant cognitive impairments and increased oxidative stress, marked by elevated malondialdehyde (MDA) and decreased superoxide dismutase (SOD) and glutathione (GSH) levels. Behavioral tests, including the Morris Water Maze (MWM) as well as Passive Avoidance Learning (PAL) tasks, confirmed memory and learning deficits in the TBHQ group. Histopathological analysis showed damage in the brain, liver, and kidney tissues of TBHQ-exposed rats. Chitosan treatment significantly mitigated these effects, reducing oxidative stress markers and preserving tissue integrity. These findings suggest that chitosan’s antioxidant properties may provide a therapeutic benefit against TBHQ-induced neurotoxicity and organ damage. Conclusions: These findings suggest that chitosan exerts potent neuroprotective effects, potentially through its antioxidant and anti-inflammatory properties, and could serve as a therapeutic agent against TBHQ-induced toxicity. |
| format | Article |
| id | doaj-art-6da45e79a38947dd800e08e77a0d2876 |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-6da45e79a38947dd800e08e77a0d28762025-01-25T08:55:52ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-01-013012687110.31083/FBL26871S2768-6701(24)01564-8The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male RatsShahad Alahmadi0Mohammed Mufadhe Alanazi1Fawaz Alasmari2Wedad Saeed Al-Qahtani3Gadah Albasher4Department of Zoology, College of Science, King Saud University, 11451 Riyadh, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, 11451 Riyadh, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, 11451 Riyadh, Saudi ArabiaBackground: We investigated chitosan’s protective effects against tertiary butylhydroquinone (TBHQ)-induced toxicity in adult male rats, focusing on cognitive functions and oxidative stress in the brain, liver, and kidneys. Methods: Rats were divided into four groups (n = 8/group): (1) Control, (2) Chitosan only, (3) TBHQ only, and (4) Chitosan + TBHQ. Results: TBHQ exposure led to significant cognitive impairments and increased oxidative stress, marked by elevated malondialdehyde (MDA) and decreased superoxide dismutase (SOD) and glutathione (GSH) levels. Behavioral tests, including the Morris Water Maze (MWM) as well as Passive Avoidance Learning (PAL) tasks, confirmed memory and learning deficits in the TBHQ group. Histopathological analysis showed damage in the brain, liver, and kidney tissues of TBHQ-exposed rats. Chitosan treatment significantly mitigated these effects, reducing oxidative stress markers and preserving tissue integrity. These findings suggest that chitosan’s antioxidant properties may provide a therapeutic benefit against TBHQ-induced neurotoxicity and organ damage. Conclusions: These findings suggest that chitosan exerts potent neuroprotective effects, potentially through its antioxidant and anti-inflammatory properties, and could serve as a therapeutic agent against TBHQ-induced toxicity.https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26871tbhqchitosancerebral cortexantioxidanttoxicitybehavioral test |
| spellingShingle | Shahad Alahmadi Mohammed Mufadhe Alanazi Fawaz Alasmari Wedad Saeed Al-Qahtani Gadah Albasher The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats Frontiers in Bioscience-Landmark tbhq chitosan cerebral cortex antioxidant toxicity behavioral test |
| title | The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats |
| title_full | The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats |
| title_fullStr | The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats |
| title_full_unstemmed | The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats |
| title_short | The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats |
| title_sort | efficiency of chitosan against tert butylhydroquinone tbhq induced neurobehavioral changes and toxicity effects in male rats |
| topic | tbhq chitosan cerebral cortex antioxidant toxicity behavioral test |
| url | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26871 |
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