Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1α/YAP signaling in periodontitis

Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1α/YAP signaling in periodontitis

Abstract Background Aberrant angiogenesis is an important pathological feature of periodontitis, which is regulated by angiogenic paracrine factors derived from periodontal ligament stem cells (PDLSCs). We have previously demonstrated that ubiquitin C-terminal hydrolase L1 (UCHL1) was upregulated in...

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Bibliographic Details
Main Authors: Lu Lin, Weijun Yu, Ruhan Yang, Mingzhi Liu, Yuanjie Shi, Shucheng Hu, Guanglong Li, Jiaqi Tang, Yue Shen, Zhurong Cui, Min Jin, Yuting Gu, Eryi Lu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Periodontitis
Angiogenesis
Periodontal ligament stem cells
Ubiquitin C-terminal hydrolase L1
Yes-associated protein
Online Access:https://doi.org/10.1186/s13287-025-04399-y
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https://doi.org/10.1186/s13287-025-04399-y

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