Mechanism of action of over-expressing NY-ESO-1 in vesicular stomatitis virus and its combination therapy with NY-ESO-1 TCR-T

Mechanism of action of over-expressing NY-ESO-1 in vesicular stomatitis virus and its combination therapy with NY-ESO-1 TCR-T

IntroductionVesicular stomatitis virus (VSV) is a promising oncolytic viral platform due to its short replication cycle, broad tissue tropism, low natural infection rate in humans, and a small genome that is easy to genetically manipulate. Leveraging these advantages, we developed an attenuated onco...

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Bibliographic Details
Main Authors: Ting Tian, Liang Ma, Liying Mao, Xiangxiang Wang, Longxin Cheng, Qibin Ma, Rong Xu, Guoqing Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
vesicular stomatitis virus
NY-ESO-1
tumor
TCR-T cell
combination (combined) therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617941/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617941/full

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