Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus
Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/2528956 |
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| author | Dian-dian Zhao Pei-lin Jiao Jing-jia Yu Xiao-jing Wang Lin Zhao Yan Xuan Li-hao Sun Bei Tao Wei-qing Wang Guang Ning Jian-min Liu Hong-yan Zhao |
| author_facet | Dian-dian Zhao Pei-lin Jiao Jing-jia Yu Xiao-jing Wang Lin Zhao Yan Xuan Li-hao Sun Bei Tao Wei-qing Wang Guang Ning Jian-min Liu Hong-yan Zhao |
| author_sort | Dian-dian Zhao |
| collection | DOAJ |
| description | Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs at lumbar spine (L2–4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), and creatinine (Cr) were also tested. Data analyses revealed that serum UA levels were positively associated with BMD at all sites (p<0.05) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight (r=0.322), body mass index (BMI) (r=0.331), Ca (r=0.179), and Cr (r=0.239) (p<0.001) and were also positively associated with the concentrations of PTH (r=0.10, p<0.05). When compared with those in the lowest tertile of UA levels, men with T2DM in the highest tertile had a lower prevalence of osteoporosis or osteopenia (adjusted odds ratio 0.54, 95% confidence interval [CI] 0.31–0.95). These data suggest that higher serum levels of UA are associated with higher BMDs and lower risks of osteoporosis in Chinese men with T2DM. |
| format | Article |
| id | doaj-art-6d1c5996c6cd459a9c489630c38d5c45 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6d1c5996c6cd459a9c489630c38d5c452025-02-03T07:24:49ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/25289562528956Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes MellitusDian-dian Zhao0Pei-lin Jiao1Jing-jia Yu2Xiao-jing Wang3Lin Zhao4Yan Xuan5Li-hao Sun6Bei Tao7Wei-qing Wang8Guang Ning9Jian-min Liu10Hong-yan Zhao11Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaDepartment of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, ChinaAccumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs at lumbar spine (L2–4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), and creatinine (Cr) were also tested. Data analyses revealed that serum UA levels were positively associated with BMD at all sites (p<0.05) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight (r=0.322), body mass index (BMI) (r=0.331), Ca (r=0.179), and Cr (r=0.239) (p<0.001) and were also positively associated with the concentrations of PTH (r=0.10, p<0.05). When compared with those in the lowest tertile of UA levels, men with T2DM in the highest tertile had a lower prevalence of osteoporosis or osteopenia (adjusted odds ratio 0.54, 95% confidence interval [CI] 0.31–0.95). These data suggest that higher serum levels of UA are associated with higher BMDs and lower risks of osteoporosis in Chinese men with T2DM.http://dx.doi.org/10.1155/2016/2528956 |
| spellingShingle | Dian-dian Zhao Pei-lin Jiao Jing-jia Yu Xiao-jing Wang Lin Zhao Yan Xuan Li-hao Sun Bei Tao Wei-qing Wang Guang Ning Jian-min Liu Hong-yan Zhao Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus International Journal of Endocrinology |
| title | Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus |
| title_full | Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus |
| title_fullStr | Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus |
| title_short | Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus |
| title_sort | higher serum uric acid is associated with higher bone mineral density in chinese men with type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2016/2528956 |
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