Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice
Summary: Exercise improves cognitive function in Alzheimer’s disease (AD) via mechanism that are not fully clear. Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and cognitive function in the APP/PS1 transgenic mouse (Tg) model of familial AD. Next, we pr...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225000112 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595330416246784 |
|---|---|
| author | Oliver K. Fuller Emma D. McLennan Casey L. Egan Nimna Perera Lauren V. Terry Jae Pyun Mariana de Mendonca Guilherme Defante Telles Benoit Smeuninx Emma L. Burrows Ghizal Siddiqui Darren J. Creek John W. Scott Michael A. Pearen Pamali Fonseka Joseph A. Nicolazzo Suresh Mathivanan Anthony J. Hannan Grant A. Ramm Martin Whitham Mark A. Febbraio |
| author_facet | Oliver K. Fuller Emma D. McLennan Casey L. Egan Nimna Perera Lauren V. Terry Jae Pyun Mariana de Mendonca Guilherme Defante Telles Benoit Smeuninx Emma L. Burrows Ghizal Siddiqui Darren J. Creek John W. Scott Michael A. Pearen Pamali Fonseka Joseph A. Nicolazzo Suresh Mathivanan Anthony J. Hannan Grant A. Ramm Martin Whitham Mark A. Febbraio |
| author_sort | Oliver K. Fuller |
| collection | DOAJ |
| description | Summary: Exercise improves cognitive function in Alzheimer’s disease (AD) via mechanism that are not fully clear. Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and cognitive function in the APP/PS1 transgenic mouse (Tg) model of familial AD. Next, we profiled extracellular vesicles (EVs) and examined whether they may play a role in the protective effects of VET via intranasal administration of EVs, purified from the blood of sedentary (sEV) and/or acutely exercised (eEV) donor wild-type mice into APP/PS1Tg mice. We show that VET reduced resting energy expenditure (REE) and improved cognition in APP/PS1 Tg mice. Administration of eEV, but not sEV, also reduced REE, but had no effect on cognition. Taken together, these data show that exercise is effective intervention to improve symptoms of AD in APP/PS1Tg mice. In addition, eEVs mediate some of these effects, implicating EVs in the treatment of age-related neurodegenerative diseases. |
| format | Article |
| id | doaj-art-6cb709c2015041a880b422eb557a5276 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-6cb709c2015041a880b422eb557a52762025-01-19T06:26:30ZengElsevieriScience2589-00422025-02-01282111752Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 miceOliver K. Fuller0Emma D. McLennan1Casey L. Egan2Nimna Perera3Lauren V. Terry4Jae Pyun5Mariana de Mendonca6Guilherme Defante Telles7Benoit Smeuninx8Emma L. Burrows9Ghizal Siddiqui10Darren J. Creek11John W. Scott12Michael A. Pearen13Pamali Fonseka14Joseph A. Nicolazzo15Suresh Mathivanan16Anthony J. Hannan17Grant A. Ramm18Martin Whitham19Mark A. Febbraio20Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, AustraliaMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, AustraliaLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, AustraliaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaSchool of Sport, Exercise & Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UKMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; Corresponding authorSummary: Exercise improves cognitive function in Alzheimer’s disease (AD) via mechanism that are not fully clear. Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and cognitive function in the APP/PS1 transgenic mouse (Tg) model of familial AD. Next, we profiled extracellular vesicles (EVs) and examined whether they may play a role in the protective effects of VET via intranasal administration of EVs, purified from the blood of sedentary (sEV) and/or acutely exercised (eEV) donor wild-type mice into APP/PS1Tg mice. We show that VET reduced resting energy expenditure (REE) and improved cognition in APP/PS1 Tg mice. Administration of eEV, but not sEV, also reduced REE, but had no effect on cognition. Taken together, these data show that exercise is effective intervention to improve symptoms of AD in APP/PS1Tg mice. In addition, eEVs mediate some of these effects, implicating EVs in the treatment of age-related neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S2589004225000112Molecular physiologyNeuroscienceCell biology |
| spellingShingle | Oliver K. Fuller Emma D. McLennan Casey L. Egan Nimna Perera Lauren V. Terry Jae Pyun Mariana de Mendonca Guilherme Defante Telles Benoit Smeuninx Emma L. Burrows Ghizal Siddiqui Darren J. Creek John W. Scott Michael A. Pearen Pamali Fonseka Joseph A. Nicolazzo Suresh Mathivanan Anthony J. Hannan Grant A. Ramm Martin Whitham Mark A. Febbraio Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice iScience Molecular physiology Neuroscience Cell biology |
| title | Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice |
| title_full | Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice |
| title_fullStr | Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice |
| title_full_unstemmed | Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice |
| title_short | Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice |
| title_sort | extracellular vesicles contribute to the beneficial effects of exercise training in app ps1 mice |
| topic | Molecular physiology Neuroscience Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225000112 |
| work_keys_str_mv | AT oliverkfuller extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT emmadmclennan extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT caseylegan extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT nimnaperera extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT laurenvterry extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT jaepyun extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT marianademendonca extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT guilhermedefantetelles extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT benoitsmeuninx extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT emmalburrows extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT ghizalsiddiqui extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT darrenjcreek extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT johnwscott extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT michaelapearen extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT pamalifonseka extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT josephanicolazzo extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT sureshmathivanan extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT anthonyjhannan extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT grantaramm extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT martinwhitham extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice AT markafebbraio extracellularvesiclescontributetothebeneficialeffectsofexercisetraininginappps1mice |