Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice

Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice

Summary: Exercise improves cognitive function in Alzheimer’s disease (AD) via mechanism that are not fully clear. Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and cognitive function in the APP/PS1 transgenic mouse (Tg) model of familial AD. Next, we pr...

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Main Authors: Oliver K. Fuller, Emma D. McLennan, Casey L. Egan, Nimna Perera, Lauren V. Terry, Jae Pyun, Mariana de Mendonca, Guilherme Defante Telles, Benoit Smeuninx, Emma L. Burrows, Ghizal Siddiqui, Darren J. Creek, John W. Scott, Michael A. Pearen, Pamali Fonseka, Joseph A. Nicolazzo, Suresh Mathivanan, Anthony J. Hannan, Grant A. Ramm, Martin Whitham, Mark A. Febbraio
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Molecular physiology
Neuroscience
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225000112
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http://www.sciencedirect.com/science/article/pii/S2589004225000112

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