Engineering cardiology with miniature hearts
Cardiac organoids offer sophisticated 3D structures that emulate key aspects of human heart development and function. This review traces the evolution of cardiac organoid technology, from early stem cell differentiation protocols to advanced bioengineering approaches. We discuss the methodologies fo...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000638 |
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| author | Xiaojun Xia Miner Hu Wenyan Zhou Yunpeng Jin Xudong Yao |
| author_facet | Xiaojun Xia Miner Hu Wenyan Zhou Yunpeng Jin Xudong Yao |
| author_sort | Xiaojun Xia |
| collection | DOAJ |
| description | Cardiac organoids offer sophisticated 3D structures that emulate key aspects of human heart development and function. This review traces the evolution of cardiac organoid technology, from early stem cell differentiation protocols to advanced bioengineering approaches. We discuss the methodologies for creating cardiac organoids, including self-organization techniques, biomaterial-based scaffolds, 3D bioprinting, and organ-on-chip platforms, which have significantly enhanced the structural complexity and physiological relevance of in vitro cardiac models. We examine their applications in fundamental research and medical innovations, highlighting their potential to transform our understanding of cardiac biology and pathology. The integration of multiple cell types, vascularization strategies, and maturation protocols has led to more faithful representations of the adult human heart. However, challenges remain in achieving full functional maturity and scalability. We critically assess the current limitations and outline future directions for advancing cardiac organoid technology. By providing a comprehensive analysis of the field, this review aims to catalyze further innovation in cardiac tissue engineering and facilitate its translation to clinical applications. |
| format | Article |
| id | doaj-art-6cb4e00db0084d1b942b4cdd9329d3b5 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-6cb4e00db0084d1b942b4cdd9329d3b52025-01-27T04:22:08ZengElsevierMaterials Today Bio2590-00642025-04-0131101505Engineering cardiology with miniature heartsXiaojun Xia0Miner Hu1Wenyan Zhou2Yunpeng Jin3Xudong Yao4Department of Cardiology, Center of Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, ChinaDepartment of Cardiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310000, ChinaSchool of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, ChinaDepartment of Cardiology, Center of Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China; Corresponding author.Department of Cardiology, Center of Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China; Corresponding author. Department of Cardiology, Center of Regeneration and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.Cardiac organoids offer sophisticated 3D structures that emulate key aspects of human heart development and function. This review traces the evolution of cardiac organoid technology, from early stem cell differentiation protocols to advanced bioengineering approaches. We discuss the methodologies for creating cardiac organoids, including self-organization techniques, biomaterial-based scaffolds, 3D bioprinting, and organ-on-chip platforms, which have significantly enhanced the structural complexity and physiological relevance of in vitro cardiac models. We examine their applications in fundamental research and medical innovations, highlighting their potential to transform our understanding of cardiac biology and pathology. The integration of multiple cell types, vascularization strategies, and maturation protocols has led to more faithful representations of the adult human heart. However, challenges remain in achieving full functional maturity and scalability. We critically assess the current limitations and outline future directions for advancing cardiac organoid technology. By providing a comprehensive analysis of the field, this review aims to catalyze further innovation in cardiac tissue engineering and facilitate its translation to clinical applications.http://www.sciencedirect.com/science/article/pii/S2590006425000638Cardiac organoidsTissue engineeringCardiovascular disease modelingDrug discoveryRegenerative medicine |
| spellingShingle | Xiaojun Xia Miner Hu Wenyan Zhou Yunpeng Jin Xudong Yao Engineering cardiology with miniature hearts Materials Today Bio Cardiac organoids Tissue engineering Cardiovascular disease modeling Drug discovery Regenerative medicine |
| title | Engineering cardiology with miniature hearts |
| title_full | Engineering cardiology with miniature hearts |
| title_fullStr | Engineering cardiology with miniature hearts |
| title_full_unstemmed | Engineering cardiology with miniature hearts |
| title_short | Engineering cardiology with miniature hearts |
| title_sort | engineering cardiology with miniature hearts |
| topic | Cardiac organoids Tissue engineering Cardiovascular disease modeling Drug discovery Regenerative medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000638 |
| work_keys_str_mv | AT xiaojunxia engineeringcardiologywithminiaturehearts AT minerhu engineeringcardiologywithminiaturehearts AT wenyanzhou engineeringcardiologywithminiaturehearts AT yunpengjin engineeringcardiologywithminiaturehearts AT xudongyao engineeringcardiologywithminiaturehearts |