PPARγ and Its Role in Cardiovascular Diseases
Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. The activators of PPARγ are already widely used in the treatment of diabet...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2017/6404638 |
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| _version_ | 1832547577589923840 |
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| author | Mini Chandra Sumitra Miriyala Manikandan Panchatcharam |
| author_facet | Mini Chandra Sumitra Miriyala Manikandan Panchatcharam |
| author_sort | Mini Chandra |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. The activators of PPARγ are already widely used in the treatment of diabetes mellitus. The cardioprotective effect of PPARγ activation has been studied extensively over the years making them potential therapeutic targets in diseases associated with cardiovascular disorders. However, they are also associated with adverse cardiovascular events such as congestive heart failure and myocardial infarction. This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials. Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects. |
| format | Article |
| id | doaj-art-6cae0ca6175b4bde9486b33d54ef0c89 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-6cae0ca6175b4bde9486b33d54ef0c892025-02-03T06:44:23ZengWileyPPAR Research1687-47571687-47652017-01-01201710.1155/2017/64046386404638PPARγ and Its Role in Cardiovascular DiseasesMini Chandra0Sumitra Miriyala1Manikandan Panchatcharam2Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USADepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USADepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USAPeroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. The activators of PPARγ are already widely used in the treatment of diabetes mellitus. The cardioprotective effect of PPARγ activation has been studied extensively over the years making them potential therapeutic targets in diseases associated with cardiovascular disorders. However, they are also associated with adverse cardiovascular events such as congestive heart failure and myocardial infarction. This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials. Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.http://dx.doi.org/10.1155/2017/6404638 |
| spellingShingle | Mini Chandra Sumitra Miriyala Manikandan Panchatcharam PPARγ and Its Role in Cardiovascular Diseases PPAR Research |
| title | PPARγ and Its Role in Cardiovascular Diseases |
| title_full | PPARγ and Its Role in Cardiovascular Diseases |
| title_fullStr | PPARγ and Its Role in Cardiovascular Diseases |
| title_full_unstemmed | PPARγ and Its Role in Cardiovascular Diseases |
| title_short | PPARγ and Its Role in Cardiovascular Diseases |
| title_sort | pparγ and its role in cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2017/6404638 |
| work_keys_str_mv | AT minichandra pparganditsroleincardiovasculardiseases AT sumitramiriyala pparganditsroleincardiovasculardiseases AT manikandanpanchatcharam pparganditsroleincardiovasculardiseases |