Drug-induced reactivation of apoptosis abrogates HIV-1 infection.

Drug-induced reactivation of apoptosis abrogates HIV-1 infection.

HIV-1 blocks apoptosis, programmed cell death, an innate defense of cells against viral invasion. However, apoptosis can be selectively reactivated in HIV-infected cells by chemical agents that interfere with HIV-1 gene expression. We studied two globally used medicines, the topical antifungal ciclo...

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Main Authors: Hartmut M Hanauske-Abel, Deepti Saxena, Paul E Palumbo, Axel-Rainer Hanauske, Augusto D Luchessi, Tavane D Cambiaghi, Mainul Hoque, Michael Spino, Darlene D'Alliessi Gandolfi, Debra S Heller, Sukhwinder Singh, Myung Hee Park, Bernadette M Cracchiolo, Fernando Tricta, John Connelly, Anthony M Popowicz, Richard A Cone, Bart Holland, Tsafi Pe'ery, Michael B Mathews
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074414&type=printable
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