Higher levels of D2R and D3R in the frontal–striatal regions are associated with reduced perseverative reward seeking after opioid abstinence

Higher levels of D2R and D3R in the frontal–striatal regions are associated with reduced perseverative reward seeking after opioid abstinence

IntroductionThe lower levels of dopamine D2 receptor (D2R) in the striatum and the heightened levels of dopamine D2 receptor (D3R) in the midbrain have been linked to impulsive behavior and risky decision-making associated with drug dependence. While D3R has been considered a potential target for tr...

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Bibliographic Details
Main Authors: Yingying Li, Xigeng Zheng, Cong Gao, Shao Li, Zhengkui Liu, Meixuan Lv, Fei Xiao, Yunjing Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
morphine
reward seeking
perseveration
D2/D3
striatum
prefrontal cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1552055/full
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https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1552055/full

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