Carrier-Based Drug Delivery System for Treatment of Acne
Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/276260 |
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| author | Amber Vyas Avinesh Kumar Sonker Bina Gidwani |
| author_facet | Amber Vyas Avinesh Kumar Sonker Bina Gidwani |
| author_sort | Amber Vyas |
| collection | DOAJ |
| description | Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system. |
| format | Article |
| id | doaj-art-6c2a6aa2d08a4f84a58986a7a89eadbe |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6c2a6aa2d08a4f84a58986a7a89eadbe2025-02-03T01:31:09ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/276260276260Carrier-Based Drug Delivery System for Treatment of AcneAmber Vyas0Avinesh Kumar Sonker1Bina Gidwani2University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur 492 010, IndiaUniversity Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur 492 010, IndiaUniversity Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur 492 010, IndiaApproximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system.http://dx.doi.org/10.1155/2014/276260 |
| spellingShingle | Amber Vyas Avinesh Kumar Sonker Bina Gidwani Carrier-Based Drug Delivery System for Treatment of Acne The Scientific World Journal |
| title | Carrier-Based Drug Delivery System for Treatment of Acne |
| title_full | Carrier-Based Drug Delivery System for Treatment of Acne |
| title_fullStr | Carrier-Based Drug Delivery System for Treatment of Acne |
| title_full_unstemmed | Carrier-Based Drug Delivery System for Treatment of Acne |
| title_short | Carrier-Based Drug Delivery System for Treatment of Acne |
| title_sort | carrier based drug delivery system for treatment of acne |
| url | http://dx.doi.org/10.1155/2014/276260 |
| work_keys_str_mv | AT ambervyas carrierbaseddrugdeliverysystemfortreatmentofacne AT avineshkumarsonker carrierbaseddrugdeliverysystemfortreatmentofacne AT binagidwani carrierbaseddrugdeliverysystemfortreatmentofacne |