Finding Genetic Risk Factors of Gestational Diabetes
Gestational diabetes mellitus (GDM) is a complex metabolic disorder of pregnancy that is suspected to have a strong genetic predisposition. It is associated with poor perinatal outcome, and both GDM women and their offspring are at increased risk of future development of type 2 diabetes mellitus (T2...
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BioMed Central
2012-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-10-239.pdf |
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| author | Soo Heon Kwak Hak C. Jang Kyong Soo Park |
| author_facet | Soo Heon Kwak Hak C. Jang Kyong Soo Park |
| author_sort | Soo Heon Kwak |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is a complex metabolic disorder of pregnancy that is suspected to have a strong genetic predisposition. It is associated with poor perinatal outcome, and both GDM women and their offspring are at increased risk of future development of type 2 diabetes mellitus (T2DM). During the past several years, there has been progress in finding the genetic risk factors of GDM in relation to T2DM. Some of the genetic variants that were proven to be significantly associated with T2DM are also genetic risk factors of GDM. Recently, a genome-wide association study of GDM was performed and reported that genetic variants in CDKAL1 and MTNR1B were associated with GDM at a genome-wide significance level. Current investigations using next-generation sequencing will improve our insight into the pathophysiology of GDM. It would be important to know whether genetic information revealed from these studies could improve our prediction of GDM and the future development of T2DM. We hope further research on the genetics of GDM would ultimately lead us to personalized genomic medicine and improved patient care. |
| format | Article |
| id | doaj-art-6c1f102ff1a2416788f976bfd923c72d |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-6c1f102ff1a2416788f976bfd923c72d2025-02-02T08:50:56ZengBioMed CentralGenomics & Informatics1598-866X2234-07422012-12-0110423924310.5808/GI.2012.10.4.23923Finding Genetic Risk Factors of Gestational DiabetesSoo Heon Kwak0Hak C. Jang1Kyong Soo Park2Department of Internal Medicine, Seoul National University Hospital, Seoul 110-744, Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.Department of Internal Medicine, Seoul National University Hospital, Seoul 110-744, Korea.Gestational diabetes mellitus (GDM) is a complex metabolic disorder of pregnancy that is suspected to have a strong genetic predisposition. It is associated with poor perinatal outcome, and both GDM women and their offspring are at increased risk of future development of type 2 diabetes mellitus (T2DM). During the past several years, there has been progress in finding the genetic risk factors of GDM in relation to T2DM. Some of the genetic variants that were proven to be significantly associated with T2DM are also genetic risk factors of GDM. Recently, a genome-wide association study of GDM was performed and reported that genetic variants in CDKAL1 and MTNR1B were associated with GDM at a genome-wide significance level. Current investigations using next-generation sequencing will improve our insight into the pathophysiology of GDM. It would be important to know whether genetic information revealed from these studies could improve our prediction of GDM and the future development of T2DM. We hope further research on the genetics of GDM would ultimately lead us to personalized genomic medicine and improved patient care.http://genominfo.org/upload/pdf/gni-10-239.pdfgeneticsgestational diabetestype 2 diabetes |
| spellingShingle | Soo Heon Kwak Hak C. Jang Kyong Soo Park Finding Genetic Risk Factors of Gestational Diabetes Genomics & Informatics genetics gestational diabetes type 2 diabetes |
| title | Finding Genetic Risk Factors of Gestational Diabetes |
| title_full | Finding Genetic Risk Factors of Gestational Diabetes |
| title_fullStr | Finding Genetic Risk Factors of Gestational Diabetes |
| title_full_unstemmed | Finding Genetic Risk Factors of Gestational Diabetes |
| title_short | Finding Genetic Risk Factors of Gestational Diabetes |
| title_sort | finding genetic risk factors of gestational diabetes |
| topic | genetics gestational diabetes type 2 diabetes |
| url | http://genominfo.org/upload/pdf/gni-10-239.pdf |
| work_keys_str_mv | AT sooheonkwak findinggeneticriskfactorsofgestationaldiabetes AT hakcjang findinggeneticriskfactorsofgestationaldiabetes AT kyongsoopark findinggeneticriskfactorsofgestationaldiabetes |