Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis

Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis

Introduction: Pulmonary fibrosis (PF) is a fatal fibrotic lung disease without any options to halt disease progression. Feasible evidence suggests that aberrant metabolism of amino acids may play a role in the pathoetiology of PF. However, the exact impact of kynurenine (Kyn), a metabolite derived f...

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Main Authors: Yi Wang, Guo-Rao Wu, Huihui Yue, Qing Zhou, Lei Zhang, Long He, Weikuan Gu, Rongfen Gao, Lingli Dong, Huilan Zhang, Jianping Zhao, Xiansheng Liu, Weining Xiong, Cong-Yi Wang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Advanced Research
Subjects:
Pulmonary fibrosis
Indoleamine 2,3-dioxygenase 1
Tryptophan
Kynurenine
Fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224002546
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