Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers
Individual differences in environmental sensitivity are linked to stress-related psychiatric symptoms. In previous research, we found that high environmental sensitivity can be a risk factor for increased inflammation and gut permeability, particularly when gut microbiome diversity is low. However,...
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MDPI AG
2025-01-01
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| author | Satoshi Takasugi Shuhei Iimura Miyabi Yasuda Yoshie Saito Masashi Morifuji |
| author_facet | Satoshi Takasugi Shuhei Iimura Miyabi Yasuda Yoshie Saito Masashi Morifuji |
| author_sort | Satoshi Takasugi |
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| description | Individual differences in environmental sensitivity are linked to stress-related psychiatric symptoms. In previous research, we found that high environmental sensitivity can be a risk factor for increased inflammation and gut permeability, particularly when gut microbiome diversity is low. However, the specific gut bacterial taxa involved in this interaction remain unclear. As a preliminary study, this research aimed to identify the key gut microbiome taxa associated with this relationship. Environmental sensitivity, gut microbiome composition, gut permeability (lipopolysaccharide-binding protein, LBP), and inflammation (C-reactive protein, CRP) biomarkers were evaluated in 88 participants. The interaction between environmental sensitivity and the relative abundance of the family <i>Marinifilaceae</i> (genus <i>Butyricimonas</i>) was a predictor of CRP levels. Similarly, the interaction between environmental sensitivity and relative abundance of the family <i>Barnesiellaceae</i> (genus <i>Coprobacter</i>), the family <i>Akkermansiaceae</i> (genus <i>Akkermansia</i>), the genus <i>Family XIII AD3011 group</i>, the genus <i>GCA-900066225</i>, or the genus <i>Ruminiclostridium 1</i> predicted LBP levels. Individuals with high environmental sensitivity exhibited elevated CRP or LBP levels when the relative abundance of these taxa was low. Conversely, highly sensitive individuals had lower CRP or LBP levels when the relative abundance of these taxa was high. This study suggests that specific taxa serve as one of the protective factors against inflammation and gut permeability in individuals with high environmental sensitivity. Further in-depth studies are needed to confirm these associations and understand the underlying mechanisms. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Microorganisms |
| spelling | doaj-art-6c05a2a9574147ef859e95c79e1848db2025-01-24T13:42:58ZengMDPI AGMicroorganisms2076-26072025-01-0113118510.3390/microorganisms13010185Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related BiomarkersSatoshi Takasugi0Shuhei Iimura1Miyabi Yasuda2Yoshie Saito3Masashi Morifuji4R&D Division, Meiji Co., Ltd., 1-29-1 Nanakuni, Hachioji 192-0919, JapanFaculty of Education, Soka University; 1-236 Tangi-machi, Hachioji 192-8577, JapanWellness Science Labs, Meiji Holdings Co., Ltd., 1-29-1 Nanakuni, Hachioji 192-0919, JapanWellness Science Labs, Meiji Holdings Co., Ltd., 1-29-1 Nanakuni, Hachioji 192-0919, JapanWellness Science Labs, Meiji Holdings Co., Ltd., 1-29-1 Nanakuni, Hachioji 192-0919, JapanIndividual differences in environmental sensitivity are linked to stress-related psychiatric symptoms. In previous research, we found that high environmental sensitivity can be a risk factor for increased inflammation and gut permeability, particularly when gut microbiome diversity is low. However, the specific gut bacterial taxa involved in this interaction remain unclear. As a preliminary study, this research aimed to identify the key gut microbiome taxa associated with this relationship. Environmental sensitivity, gut microbiome composition, gut permeability (lipopolysaccharide-binding protein, LBP), and inflammation (C-reactive protein, CRP) biomarkers were evaluated in 88 participants. The interaction between environmental sensitivity and the relative abundance of the family <i>Marinifilaceae</i> (genus <i>Butyricimonas</i>) was a predictor of CRP levels. Similarly, the interaction between environmental sensitivity and relative abundance of the family <i>Barnesiellaceae</i> (genus <i>Coprobacter</i>), the family <i>Akkermansiaceae</i> (genus <i>Akkermansia</i>), the genus <i>Family XIII AD3011 group</i>, the genus <i>GCA-900066225</i>, or the genus <i>Ruminiclostridium 1</i> predicted LBP levels. Individuals with high environmental sensitivity exhibited elevated CRP or LBP levels when the relative abundance of these taxa was low. Conversely, highly sensitive individuals had lower CRP or LBP levels when the relative abundance of these taxa was high. This study suggests that specific taxa serve as one of the protective factors against inflammation and gut permeability in individuals with high environmental sensitivity. Further in-depth studies are needed to confirm these associations and understand the underlying mechanisms.https://www.mdpi.com/2076-2607/13/1/185environmental sensitivitysensory processing sensitivitygut microbiomeinflammationgut barriergut-brain axis |
| spellingShingle | Satoshi Takasugi Shuhei Iimura Miyabi Yasuda Yoshie Saito Masashi Morifuji Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers Microorganisms environmental sensitivity sensory processing sensitivity gut microbiome inflammation gut barrier gut-brain axis |
| title | Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers |
| title_full | Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers |
| title_fullStr | Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers |
| title_full_unstemmed | Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers |
| title_short | Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers |
| title_sort | key taxa of the gut microbiome associated with the relationship between environmental sensitivity and inflammation related biomarkers |
| topic | environmental sensitivity sensory processing sensitivity gut microbiome inflammation gut barrier gut-brain axis |
| url | https://www.mdpi.com/2076-2607/13/1/185 |
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