Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome

Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome

Thoracic aortic aneurysm (TAA) significantly endangers the lives of individuals with Marfan syndrome (MFS), yet the intricacies of their biomechanical origins remain elusive. Our investigation delves into the pivotal role of hemodynamic disturbance in the pathogenesis of TAA, with a particular empha...

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Bibliographic Details
Main Authors: Ming-Yuan Liu, Meili Wang, Junjun Liu, An-Qiang Sun, Chang-Shun He, Xin Cong, Wei Kong, Wei Li
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Thoracic aortic aneurysm (TAA)
mTORC1
Marfan syndrome
Biomechanicalpathogenesis
Wall shear stress (WSS)
Online Access:http://www.sciencedirect.com/science/article/pii/S209517792400217X
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