Secondary ions mass spectrometric method for assessing surface density of pegylated liposomal nanomedicines

Secondary ions mass spectrometric method for assessing surface density of pegylated liposomal nanomedicines

Abstract Liposomal drug delivery relies on polyethylene glycol (PEG) coating since it is essential for preserving the stability and increasing the plasma half-life of the lipid-based nanocarriers, and therefore it represents a critical quality attribute of nanomedicine formulations. Due to the compl...

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Bibliographic Details
Main Authors: Francesco Fumagalli, Alexander Welle, Guillaume Bucher, Silvia Appleton, Jessica Ponti, Giacomo Ceccone, Luigi Calzolai, Dora Mehn
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Nanomedicines
Lipid-based nanoparticles
Surface properties
Advanced functional coatings
PEG
Cryogenic methods
Online Access:https://doi.org/10.1038/s41598-025-03947-z
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https://doi.org/10.1038/s41598-025-03947-z

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