Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear family of ligand activated transcriptional factors and comprise three different isoforms, PPAR-α, PPAR-β/δ, and PPAR-γ. The main role of PPARs is to regulate the expression of genes involved in lipid and glucose metabolism. Se...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2015/271983 |
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| author | Wang-Soo Lee Jaetaek Kim |
| author_facet | Wang-Soo Lee Jaetaek Kim |
| author_sort | Wang-Soo Lee |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear family of ligand activated transcriptional factors and comprise three different isoforms, PPAR-α, PPAR-β/δ, and PPAR-γ. The main role of PPARs is to regulate the expression of genes involved in lipid and glucose metabolism. Several studies have demonstrated that PPAR agonists improve dyslipidemia and glucose control in animals, supporting their potential as a promising therapeutic option to treat diabetes and dyslipidemia. However, substantial differences exist in the therapeutic or adverse effects of specific drug candidates, and clinical studies have yielded inconsistent data on their cardioprotective effects. This review summarizes the current knowledge regarding the molecular function of PPARs and the mechanisms of the PPAR regulation by posttranslational modification in the heart. We also describe the results and lessons learned from important clinical trials on PPAR agonists and discuss the potential future directions for this class of drugs. |
| format | Article |
| id | doaj-art-6bc12fe6d2264841a7ac37a6aa578d6b |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-6bc12fe6d2264841a7ac37a6aa578d6b2025-02-03T01:23:00ZengWileyPPAR Research1687-47571687-47652015-01-01201510.1155/2015/271983271983Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future DirectionsWang-Soo Lee0Jaetaek Kim1Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul 06973, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul 06973, Republic of KoreaPeroxisome proliferator-activated receptors (PPARs) belong to the nuclear family of ligand activated transcriptional factors and comprise three different isoforms, PPAR-α, PPAR-β/δ, and PPAR-γ. The main role of PPARs is to regulate the expression of genes involved in lipid and glucose metabolism. Several studies have demonstrated that PPAR agonists improve dyslipidemia and glucose control in animals, supporting their potential as a promising therapeutic option to treat diabetes and dyslipidemia. However, substantial differences exist in the therapeutic or adverse effects of specific drug candidates, and clinical studies have yielded inconsistent data on their cardioprotective effects. This review summarizes the current knowledge regarding the molecular function of PPARs and the mechanisms of the PPAR regulation by posttranslational modification in the heart. We also describe the results and lessons learned from important clinical trials on PPAR agonists and discuss the potential future directions for this class of drugs.http://dx.doi.org/10.1155/2015/271983 |
| spellingShingle | Wang-Soo Lee Jaetaek Kim Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions PPAR Research |
| title | Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions |
| title_full | Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions |
| title_fullStr | Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions |
| title_short | Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions |
| title_sort | peroxisome proliferator activated receptors and the heart lessons from the past and future directions |
| url | http://dx.doi.org/10.1155/2015/271983 |
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