A Pre-Column Derivatization Method for the HPLC-FLD Determination of Dimethyl and Diethyl Amine in Pharmaceuticals

A Pre-Column Derivatization Method for the HPLC-FLD Determination of Dimethyl and Diethyl Amine in Pharmaceuticals

In recent years, the detection of nitrosamine precursors has become an important issue for regulatory authorities such as the European Medicines Agency (EMA) and the Food and Drug Administration (FDA). The present study provides a pre-column derivatization method for the analysis of dimethylamine (D...

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Bibliographic Details
Main Authors: Georgios Kamaris, Maria Tsami, Georgiana-Roxana Lotca, Sofia Almpani, Catherine K. Markopoulou
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
HPLC-FLD
diethylamine and dimethylamine
NBD-Cl
pre-column derivatization
SPE
pharmaceuticals
Online Access:https://www.mdpi.com/1420-3049/29/23/5535
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