Antagonizing microRNA‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice

Antagonizing microRNA‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice

Abstract Postmenopausal bone loss often leads to osteoporosis and fragility fractures. Bone mass can be increased by the first 34 amino acids of human parathyroid hormone (PTH), parathyroid hormone‐related protein (PTHrP), or by a monoclonal antibody against sclerostin (Scl‐Ab). Here, we show that P...

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Main Authors: Hanna Taipaleenmäki, Hiroaki Saito, Saskia Schröder, Miki Maeda, Ramona Mettler, Matthias Ring, Ewa Rollmann, Andreas Gasser, Carl Haasper, Thorsten Gehrke, Alexander Weiss, Steffen K Grimm, Eric Hesse
Format: Article
Language:English
Published: Springer Nature 2022-10-01
Series:EMBO Molecular Medicine
Subjects:
anti‐miRNA
osteoporosis
parathyroid hormone
Tgif1
treatment
Online Access:https://doi.org/10.15252/emmm.202013617
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https://doi.org/10.15252/emmm.202013617

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