DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status

DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status

Intervertebral disc (IVD) degeneration is the primary cause for low back pain that has a high prevalence in modern society and poses enormous economic burden on patients. Few effective therapeutic strategies are available for IVD degeneration treatment. To understand the biological effects of dental...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiwen Dong, Fanqi Hu, Jing Yi, Yuning Zhang, Chao Liu, Panpan Geng, Han Duan, Chu-Tse Wu, Xuesong Zhang, Hua Wang
Format:	Article
Language:	English
Published:	Wiley 2022-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2022/7590337
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration
by: Chang Liu, et al.
Published: (2021-01-01)

Mesenchymal Stem Cells May Alleviate the Intervertebral Disc Degeneration by Reducing the Oxidative Stress in Nucleus Pulposus Cells
by: Yongzhao Zhao, et al.
Published: (2022-01-01)

Nucleus pulposus cell network modelling in the intervertebral disc
by: Sofia Tseranidou, et al.
Published: (2025-01-01)

PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration
by: Weixing Xu, et al.
Published: (2025-02-01)

Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration
by: Daxue Zhu, et al.
Published: (2025-01-01)

Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity
by: Yi Sun, et al.
Published: (2025-01-01)

The Differential Effects of Leukocyte-Containing and Pure Platelet-Rich Plasma on Nucleus Pulposus-Derived Mesenchymal Stem Cells: Implications for the Clinical Treatment of Intervertebral Disc Degeneration
by: Jun Jia, et al.
Published: (2018-01-01)

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress
by: Zaishi Zhu, et al.
Published: (2025-02-01)

Role of macrophage in intervertebral disc degeneration
by: Yiming Dou, et al.
Published: (2025-01-01)

Retracted: Effect of Fas and Bcl-2 DNA Damages Response Expression in Stem Cells on Apoptosis of Nucleus Pulposus of Intervertebral Disc
by: Stem Cells International
Published: (2024-01-01)

CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy
by: Yongbo Zhang, et al.
Published: (2025-02-01)

Effects of Stromal Cell-Derived Factor-1α Secreted in Degenerative Intervertebral Disc on Activation and Recruitment of Nucleus Pulposus-Derived Stem Cells
by: Jinwei Ying, et al.
Published: (2019-01-01)

Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
by: Zhangfu Li, et al.
Published: (2023-01-01)

The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration
by: Xianxu Zhang, et al.
Published: (2025-01-01)

The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair
by: Yingjie Mai, et al.
Published: (2025-03-01)

Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration
by: Umile Giuseppe Longo, et al.
Published: (2012-01-01)

Lumbar Intervertebral Disc Degeneration Does Not Affect Muscle Synergy for Rowing Activities
by: Chie Sekine, et al.
Published: (2021-01-01)

Automated diagnosis and grading of lumbar intervertebral disc degeneration based on a modified YOLO framework
by: Aobo Wang, et al.
Published: (2025-01-01)

Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration
by: Fudong Li, et al.
Published: (2024-01-01)

The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
by: Hao Li, et al.
Published: (2022-01-01)

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions
by: Arjun Sinkemani, et al.
Published: (2020-01-01)

Intervertebral disc regeneration – Is it possible?
by: Dragos Schiopu, et al.
Published: (2024-11-01)

The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives
by: Shangze Li, et al.
Published: (2025-02-01)

Fluoroscopy Assisted Minimally Invasive Transplantation of Allogenic Mesenchymal Stromal Cells Embedded in HyStem Reduces the Progression of Nucleus Pulposus Degeneration in the Damaged Interverbal Disc: A Preliminary Study in Rabbits
by: Rifa Aquidah Subhan, et al.
Published: (2014-01-01)

Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation
by: Zhendong He, et al.
Published: (2025-12-01)

Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP
by: Tongzhou Liang, et al.
Published: (2021-01-01)

The Degree of Cervical Intervertebral Disc Degeneration Is Associated With Denser Bone Quality of the Cervical Sub‐endplate and Vertebral Body
by: Jia‐Yu Chen, et al.
Published: (2025-02-01)

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration
by: Salvador Cervin Serrano, et al.
Published: (2014-01-01)

CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study
by: Jiang N, et al.
Published: (2025-01-01)

Hyperexcitability in Spinal WDR Neurons following Experimental Disc Herniation Is Associated with Upregulation of Fractalkine and Its Receptor in Nucleus Pulposus and the Dorsal Root Ganglion
by: Daniel Pitz Jacobsen, et al.
Published: (2016-01-01)

Identification of the Hub Genes Involved in Stem Cell Treatment for Intervertebral Disc Degeneration: A Conjoint Analysis of Single-Cell and Machine Learning
by: Jianfeng Chen, et al.
Published: (2023-01-01)

Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs
by: Megan Lin, et al.
Published: (2025-01-01)

Finite element models of intervertebral disc: recent advances and prospects
by: Tianze Sun, et al.
Published: (2025-12-01)

Clinical Effect of the Treatment of Lumbar Intervertebral Disc Protrusion
by: Yehui Zhou, et al.
Published: (2022-01-01)

Biomechanics of Disc Degeneration
by: V. Palepu, et al.
Published: (2012-01-01)

Effect of Compression Loading on Human Nucleus Pulposus-Derived Mesenchymal Stem Cells
by: Hang Liang, et al.
Published: (2018-01-01)

Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells
by: Hua Zhang, et al.
Published: (2022-01-01)

SNHG5/miR-299-5p/ATF2 Axis as a Biomarker in Immune Microenvironment of Intervertebral Disc Degeneration
by: Yu Shi, et al.
Published: (2022-01-01)

Retracted: Clinical Effect of the Treatment of Lumbar Intervertebral Disc Protrusion
by: Applied Bionics and Biomechanics
Published: (2023-01-01)

Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats
by: Yachao Zhao, et al.
Published: (2017-01-01)