Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer

Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer

Abstract Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumo...

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Main Authors: Jesenia M. Perez, Jolene M. Duda, Joohyun Ryu, Mihir Shetty, Subina Mehta, Pratik D. Jagtap, Andrew C. Nelson, Boris Winterhoff, Timothy J. Griffin, Timothy K. Starr, Stefani N. Thomas
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Patient-derived xenograft models (PDX)
Ovarian cancer
Proteogenomics
Mass spectrometry
Proteomics
Online Access:https://doi.org/10.1038/s41598-024-84874-3
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https://doi.org/10.1038/s41598-024-84874-3

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