Phosphoglucomutase A-mediated metabolic adaptation is essential for antibiotic and disease persistence in Mycobacterium tuberculosis

Phosphoglucomutase A-mediated metabolic adaptation is essential for antibiotic and disease persistence in Mycobacterium tuberculosis

ABSTRACT The long-term survival of Mycobacterium tuberculosis (Mtb) requires efficient use of host resources and uninterrupted access to host-derived nutrients. This is done by utilization of a highly flexible and integrated network of metabolic pathways. Phosphoglucomutase A (pgmA) is essential for...

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Main Authors: Taruna Sharma, Shaifali Tyagi, Rahul Pal, Jayendrajyoti Kundu, Sonu Kumar Gupta, Vishawjeet Barik, Vaibhav Kumar Nain, Manitosh Pandey, Prabhanjan Dwivedi, Bhishma Narayan Panda, Yashwant Kumar, Ranjan Kumar Nanda, Samrat Chatterjee, Amit Kumar Pandey
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSystems
Subjects:
Mycobacterium tuberculosis
phosphoglucomutase A
pgmA
glycogen metabolism
virulence
antibiotic tolerance
Online Access:https://journals.asm.org/doi/10.1128/msystems.00420-25
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