Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma
A 76-year-old woman presented with lower abdominal pain and nausea and was referred to the gastroenterology department in our institution. Previous contrast-enhanced computed tomography (CE-CT) for follow-up after breast cancer surgery had indicated a soft tissue mass below the right diaphragm, whic...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/2092157 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559282268143616 |
|---|---|
| author | Yasuo Otsuka Yoriaki Komeda Masayuki Takeda Takayuki Takahama Masashi Kono Mamoru Takenaka Satoru Hagiwara Naoshi Nishida Hiroshi Kashida Masatoshi Kudo |
| author_facet | Yasuo Otsuka Yoriaki Komeda Masayuki Takeda Takayuki Takahama Masashi Kono Mamoru Takenaka Satoru Hagiwara Naoshi Nishida Hiroshi Kashida Masatoshi Kudo |
| author_sort | Yasuo Otsuka |
| collection | DOAJ |
| description | A 76-year-old woman presented with lower abdominal pain and nausea and was referred to the gastroenterology department in our institution. Previous contrast-enhanced computed tomography (CE-CT) for follow-up after breast cancer surgery had indicated a soft tissue mass below the right diaphragm, which was considered a benign change. CE-CT performed at the first visit to our department revealed further thickening of the soft tissue mass with extension to the liver surface. In addition, ascites and nodules were observed in the abdominal cavity. Histopathological examination of a biopsy specimen revealed peritoneal invasion of atypical epithelioid cells with trabecular and glandular patterns. The tumor cells were positive for AE1/AE2, calretinin, WT-1, D2-40, HEG1, EMA, BAP1, and MTAP and negative for carcinoembryonic antigen, MOC-31, Ber-Ep4, ER, PgR, TTF-1, claudin 4, and desmin. A diagnosis of epithelioid mesothelioma was made. The patient received chemotherapy with cisplatin (75 mg/m2) and pemetrexed (500 mg/m2). After six courses of combined chemotherapy, pemetrexed was administered as a single agent. At the time of writing this report, she was undergoing over the 30th course of chemotherapy without any significant side effects. Diffuse malignant peritoneal mesothelioma is a rare, fatal, and progressive disease. Our patient achieved long-term survival of more than 5 years with maintenance therapy using single-agent pemetrexed. |
| format | Article |
| id | doaj-art-6aa6440a1f064fc6ac0c328dedb5806e |
| institution | Kabale University |
| issn | 1687-9635 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-6aa6440a1f064fc6ac0c328dedb5806e2025-02-03T01:30:25ZengWileyCase Reports in Medicine1687-96352023-01-01202310.1155/2023/2092157Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal MesotheliomaYasuo Otsuka0Yoriaki Komeda1Masayuki Takeda2Takayuki Takahama3Masashi Kono4Mamoru Takenaka5Satoru Hagiwara6Naoshi Nishida7Hiroshi Kashida8Masatoshi Kudo9Department of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Cancer Genomics and Medical OncologyDepartment of Medical OncologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyA 76-year-old woman presented with lower abdominal pain and nausea and was referred to the gastroenterology department in our institution. Previous contrast-enhanced computed tomography (CE-CT) for follow-up after breast cancer surgery had indicated a soft tissue mass below the right diaphragm, which was considered a benign change. CE-CT performed at the first visit to our department revealed further thickening of the soft tissue mass with extension to the liver surface. In addition, ascites and nodules were observed in the abdominal cavity. Histopathological examination of a biopsy specimen revealed peritoneal invasion of atypical epithelioid cells with trabecular and glandular patterns. The tumor cells were positive for AE1/AE2, calretinin, WT-1, D2-40, HEG1, EMA, BAP1, and MTAP and negative for carcinoembryonic antigen, MOC-31, Ber-Ep4, ER, PgR, TTF-1, claudin 4, and desmin. A diagnosis of epithelioid mesothelioma was made. The patient received chemotherapy with cisplatin (75 mg/m2) and pemetrexed (500 mg/m2). After six courses of combined chemotherapy, pemetrexed was administered as a single agent. At the time of writing this report, she was undergoing over the 30th course of chemotherapy without any significant side effects. Diffuse malignant peritoneal mesothelioma is a rare, fatal, and progressive disease. Our patient achieved long-term survival of more than 5 years with maintenance therapy using single-agent pemetrexed.http://dx.doi.org/10.1155/2023/2092157 |
| spellingShingle | Yasuo Otsuka Yoriaki Komeda Masayuki Takeda Takayuki Takahama Masashi Kono Mamoru Takenaka Satoru Hagiwara Naoshi Nishida Hiroshi Kashida Masatoshi Kudo Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma Case Reports in Medicine |
| title | Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma |
| title_full | Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma |
| title_fullStr | Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma |
| title_full_unstemmed | Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma |
| title_short | Long-Term Survival of More than 5 Years with Maintenance Therapy Using Single-Agent Pemetrexed in a Patient with Diffuse Malignant Peritoneal Mesothelioma |
| title_sort | long term survival of more than 5 years with maintenance therapy using single agent pemetrexed in a patient with diffuse malignant peritoneal mesothelioma |
| url | http://dx.doi.org/10.1155/2023/2092157 |
| work_keys_str_mv | AT yasuootsuka longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT yoriakikomeda longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT masayukitakeda longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT takayukitakahama longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT masashikono longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT mamorutakenaka longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT satoruhagiwara longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT naoshinishida longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT hiroshikashida longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma AT masatoshikudo longtermsurvivalofmorethan5yearswithmaintenancetherapyusingsingleagentpemetrexedinapatientwithdiffusemalignantperitonealmesothelioma |