An injectable shape-adaptive hydrogel system for subconjunctival injuries: In situ and permanently releases rapamycin to prevent fibrosis via promoting autophagy

An injectable shape-adaptive hydrogel system for subconjunctival injuries: In situ and permanently releases rapamycin to prevent fibrosis via promoting autophagy

Subconjunctival fibrosis (SCF) is a common and refractory eye disease that is a serious threat to vision. The severe side effects of existing drugs and low drug bioavailability due to the ocular barrier are major challenges in SCF treatment. Hence, there is an urgent need to explore safer and more e...

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Bibliographic Details
Main Authors: Xue Sun, Haohao Cui, Jingfan Li, Boyuan An, Ruixing Liu, Zhihua Guo, Dandan Chu, Xingchen Geng, Bingbing Cui, Lei Zhu, Jingguo Li, Zhanrong Li
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Materials Today Bio
Subjects:
Subconjunctival fibrosis
Rapamycin
In situ hydrogel
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424004411
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